Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Sava, Cristian; Bodog, Teodora-Maria; Niulas, Larisa Roxana; Iuhas, Alin Remus; Marinău, Cristian Phillip; Negruț, Nicoleta; Balmoș, Andreea Bianca; Pasca, Bianca; Roman, Nadinne; Nistor-Cseppentö, Delia Carmen

doi:10.21873/invivo.13019

In Vivo

2022

DOI: 10.21873/invivo.13019

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Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Cristian Sava

Teodora-Maria Bodog

Larisa Roxana Niulas

et al.

Abstract: Background/Aim: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for generating a global pandemic with deadly consequences and life changes worldwide. With the appearance of the new variants of the virus, clinical manifestations have been reported in the pediatric population, some with severe evolution. The aim of this study was to identify the laboratory parameters necessary to establish an effective therapy. Patients and Methods: In the period from August 2020 to Septembe… Show more

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Cited by 5 publications

References 56 publications

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Difficulties in the management of an Askin tumor in a pediatric patient with cystic fibrosis: case report and literature review

Marinău,

Csep,

Sava

et al. 2023

Front. Pediatr.

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Treating Ewing's Sarcoma of the thorax (Askin's tumor) with antineoplastic therapy in a malnourished cystic fibrosis patient colonized with Pseudomonas aeruginosa and Staphylococcus aureus may carry a significant potential for complications. We present the case of a known cystic fibrosis patient, diagnosed with Askin's tumor 5 years ago. Despite facing severe neutropenia, exacerbations of cystic fibrosis with Pseudomonas aeruginosa infections, and challenges in maintaining adequate caloric intake during the oncological treatment, the patient's outcome has been favorable. Chemotherapy doses had to be adjusted, and continuous antibiotic treatment was introduced throughout the course of therapy to reduce the frequency and intensity of exacerbations. Approximately 5 years after the cancer diagnosis, with no signs of relapse, the patient was started on CFTR (Cystic fibrosis transmembrane conductance regulator) modulator treatment. This intervention has successfully corrected the weight deficit. The coincidence of Ewing's sarcoma of the chest wall and cystic fibrosis in a single patient is 2.857 × 10−5% and to the best of our knowledge, this scenario has not been documented before.

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Difficulties in the management of an Askin tumor in a pediatric patient with cystic fibrosis: case report and literature review

Marinău,

Csep,

Sava

et al. 2023

Front. Pediatr.

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Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

Pavelescu,

Dinulescu,

Păsărică

et al. 2024

Front. Pediatr.

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BackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these parameters in children diagnosed with COVID 19.MethodsAt the time of admission, children with COVID 19 suggestive symptoms were tested RT-PCR for SARS CoV-2 and were allocated to either the study group (RT-PCR SARS CoV-2 positive) or control group (RT-PCR SARS CoV-2 negative). All children were evaluated by complete blood count, CRP, and transaminases.ResultsWhen comparing the two groups, we identified significantly lower values for leukocytes (p < 0.001), neutrophils (p < 0.001), lymphocytes (p < 0.001) and thrombocytes (p = 0.014), but no significantly different values for CRP (p = 0.916) and monocytes (p = 0.082). A diagnostic score for COVID-19 was compiled using the abovementioned parameters—presence of fever, number of lymphocytes and aspartate-aminotransferase. Performance was tested, showing a positive discrimination value (AUC of 0.703)—81.5% sensitivity, 50.6% specificity.ConclusionsThe leukocytes, neutrophils and lymphocytes have significantly lower values in COVID-19 children. The proposed score based on the presence of fever the values of lymphocytes and AST has a good sensitivity in predicting COVID-19 infection.

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The Multisystem Impact of Long COVID: A Comprehensive Review

Negrut,

Menegas,

Kampioti

et al. 2024

Diagnostics

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(1) Background: COVID-19 was responsible for the latest pandemic, shaking and reshaping healthcare systems worldwide. Its late clinical manifestations make it linger in medical memory as a debilitating illness over extended periods. (2) Methods: the recent literature was systematically analyzed to categorize and examine the symptomatology and pathophysiology of Long COVID across various bodily systems, including pulmonary, cardiovascular, gastrointestinal, neuropsychiatric, dermatological, renal, hematological, and endocrinological aspects. (3) Results: The review outlines the diverse clinical manifestations of Long COVID across multiple systems, emphasizing its complexity and challenges in diagnosis and treatment. Factors such as pre-existing conditions, initial COVID-19 severity, vaccination status, gender, and age were identified as influential in the manifestation and persistence of Long COVID symptoms. This condition is highlighted as a debilitating disease capable of enduring over an extended period and presenting new symptoms over time. (4) Conclusions: Long COVID emerges as a condition with intricate multi-systemic involvement, complicating its diagnosis and treatment. The findings underscore the necessity for a nuanced understanding of its diverse manifestations to effectively manage and address the evolving nature of this condition over time.

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Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Cited by 5 publications

References 56 publications

Difficulties in the management of an Askin tumor in a pediatric patient with cystic fibrosis: case report and literature review

Difficulties in the management of an Askin tumor in a pediatric patient with cystic fibrosis: case report and literature review

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

The Multisystem Impact of Long COVID: A Comprehensive Review

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