Immune studies in dioxin-exposed Missouri residents: Quail run

Ap, Knutsen; St, Roodman; Evans, RG; Kr, Mueller; Kb, Webb; Stehr‐Green, Paul A.; Re, Hoffman; Wf, Schramm

doi:10.1007/bf01688314

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Cited by 11 publications

(1 citation statement)

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“…Studies on community residents of Quail Run Mobile Home Park (Missouri residents, USA), environmentally exposed to contaminated industrial sludge, showed a significantly decreased percentage of lymphocytes expressing CD3þ, CD4þ, and CD2þ, but the mean numbers of each of the T-cell subsets was comparable between the groups (Hoffman et al 1986;Knutsen et al 1987). Subsequent studies (Evans et al 1988;Webb et al 1989) showed significant increases associated with higher concentrations of TCDD for IgG, %CD3þ, %CD8þ, number of T-cells, percentages of CD2þ, and CD4þ/Leu-8 position.…”

Section: 14mentioning

confidence: 99%

A review of the role of lymphoma markers and occupational and environmental exposures

Hosnijeh

Heederik

Vermeulen

2012

Veterinary Quarterly

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Section: 14mentioning

confidence: 99%

A review of the role of lymphoma markers and occupational and environmental exposures

Hosnijeh

Heederik

Vermeulen

2012

Veterinary Quarterly

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Dioxins and the ah receptor

Silbergeld

Gasiewicz

1989

American J Industrial Med

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Despite continuing controversies related to public policy, information on the molecular biology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has advanced significantly over the past decade. Current understanding of the biological mechanisms of TCDD action is based upon the interactions of TCDD with a genetically expressed cytosolic macromolecule that functions as a receptor in many cells across many species. The Ah receptor recognizes TCDD and structurally similar molecules and serves as the transducing step whereby TCDD alters gene expression through the association of the TCDD:receptor complex with specific TCDD-responsive elements on the genome. Understanding these molecular events and their relevance to the organ-level manifestations of TCDD toxicity may be critical to formulating scientifically based assessments of the risk of TCDD exposure.

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