Halogenated Organic Compounds and the Human Immune System:Preliminary Report on a Study in Hobby Fishermen

Løvik, Martinus; Johansen, Hege Rebecka; Gaarder, Per Ivar; Aaberge, Ingeborg S.; Gdynia, W.; Alexander, Jason

doi:10.1007/978-3-642-61105-6_2

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…One article reported total γ-globulin levels (Jansing and Korff 1994). Four studies described a decrease in immunoglobulin levels (Halperin et al 1998;Jansing and Korff 1994;Løvik et al 1996;Neubert et al 2000), and two studies reported increased IgG Webb et al 1989). Complement levels were determined in three studies, and only one of them included both C3 and C4 ).…”

Section: Resultsmentioning

confidence: 99%

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Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

Baccarelli

Mocarelli

Patterson

et al. 2002

Environ Health Perspect

119

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Animal studies indicate that the immune system is one of the most sensitive targets of the toxic effects of 2,3,7,8-tetrachloro-p-dibenzodioxin (TCDD). TCDD inhibits immunoglobulin secretion and decreases resistance to bacterial, viral, and parasitic infections in exposed animals. Nearly 20 years after the Seveso, Italy, accident, we measured immunoglobulin and complement plasma levels in a random sample of the population in the most highly exposed zones (n = 62) and in the surrounding noncontaminated area (n = 58). Plasma IgG levels decreased with increasing TCDD plasma concentration (r = -0.35, p = 0.0002). Median IgG concentration decreased from 1,526 mg/dL in the group with the lowest (< 3.5 ppt) TCDD levels to 1,163 mg/dL in the group with the highest (20.1-89.9 ppt) TCDD levels (p = 0.002). The association was significant (p = 0.0004) after adjusting for age, sex, smoking, and consumption of domestic livestock and poultry in multiple regression analysis and persisted after exclusion of subjects with inflammatory diseases and those using antibiotics or nonsteroidal anti-inflammatory drugs. IgM, IgA, C3, and C4 plasma concentrations did not exhibit any consistent association with TCDD levels. We performed a systematic review of all the articles published between 1966 and 2001 on human subjects exposed to TCDD reporting information on circulating levels of immunoglobulins and/or complement components. The literature indicates that the evidence for effects of TCDD on humoral immunity is sparse. Methodologic issues, results, and possible sources of variation between studies are discussed. The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation.

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Section: Resultsmentioning

confidence: 99%

“…Two additional small studies, which did not include IgG measurement, found a decrease in total γ-globulin (Jansing and Korff 1994) and serum IgM (Løvik et al 1996).…”

Section: Discussionmentioning

confidence: 98%

Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

Baccarelli

Mocarelli

Patterson

et al. 2002

Environ Health Perspect

119

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Diesel exhaust particles and carbon black have adjuvant activity on the local lymph node response and systemic IgE production to ovalbumin

Løvik¹,

Høgseth²,

Gaarder³

et al. 1997

Toxicology

150

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Relation of Serum 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Level to Hematological Examination Results in Veterans of Operation Ranch Hand

Michalek

Akhtar

Longnecker

et al. 2001

Archives of Environmental Health: An International Journal

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The authors studied indices of hematologic function and exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Vietnam War veterans of Operation Ranch Hand--the Air Force unit responsible for the aerial spraying of Agent Orange and other herbicides in Vietnam. The herbicides were contaminated with TCDD. The authors measured TCDD serum levels in 1987 or later and extrapolated the result to the time of service in Vietnam. The authors studied serum TCDD level in relation to red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, white blood cell count, platelet count, and erythrocyte sedimentation rate at each of 4 physical examinations. Compared with veterans not involved in Operation Ranch Hand, those with the highest TCDD levels in Operation Ranch Hand had mean corpuscular volumes that were about 1% higher and platelet counts that were about 4% higher. These small increases were unlikely to be of clinical significance and may not have been caused by TCDD.

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Halogenated Organic Compounds and the Human Immune System:Preliminary Report on a Study in Hobby Fishermen

Cited by 4 publications

References 18 publications

Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

Diesel exhaust particles and carbon black have adjuvant activity on the local lymph node response and systemic IgE production to ovalbumin

Relation of Serum 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Level to Hematological Examination Results in Veterans of Operation Ranch Hand

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