Immune status of anaemic pregnant women

Prema, K; Ramalakshmi, B. A.; Madhavapeddi, R; Babu, S.

doi:10.1111/j.1471-0528.1982.tb03619.x

Cited by 40 publications

(21 citation statements)

References 15 publications

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“…Alguns autores têm proposto que a imunodepressão associada à anemia, deficiência de ferro ou à desnutrição severa, predispõe as pacientes grávidas a infecções 1,16 .…”

Section: Introductionunclassified

Sorologia positiva para sífilis, toxoplasmose e doença de Chagas em gestantes de primeira consulta em centros de saúde de área metropolitana, Brasil

et al. 1990

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. et al. Sorologia positiva para sífilis, toxoplasmose e doença de Chagas em gestantes de primeira consulta em centros de saúde de área metropolitana, Brasil. Rev. Saúde públ., S. Paulo, 24:373-9, 1990. RESUMO:Alguns testes sorológicos têm sido utilizados para detectar, indiretamente, a presença de possíveis agentes etiológicos infecciosos durante a gestação, que sendo transmitidos ao feto, por via placentária, causam infecções congênitas com seqüelas leves ou graves e até morte fetal. A infecção pelo Toxoplasma gondii, de distribuição universal no homem e em animais domésticos e selvagens, geralmente se apresenta assintomática, ou na forma leve sem gravidade. As formas mais graves ocorrem na infecção ocular, na infecção congênita e em indivíduos imunodeprimidos 5,10 . A infecção congênita pode levar à morte intra-uterina ou a seqüelas graves (microcefalia ou hidrocefalia), se ocorre na primeira metade da gestação; ou é assintomática se ocorre no final da gestação. Nesses casos é comum o desenvolvimento posterior de coriorretinites e manifestações neurológicas como convulsões e retardo psicomotor 18 .

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“…Alguns autores têm proposto que a imunodepressão associada à anemia, deficiência de ferro ou à desnutrição severa, predispõe as pacientes grávidas a infecções 1,16 .…”

Section: Introductionunclassified

Sorologia positiva para sífilis, toxoplasmose e doença de Chagas em gestantes de primeira consulta em centros de saúde de área metropolitana, Brasil

et al. 1990

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“…[126][127][128][129]. Impact estimates: A review by Yakoob et al [130] found that iron supplementation and iron/folate supplementation during pregnancy reduces the risk of iron deficiency anemia at term (RR 0.33; 95% CI: 0.16 to 0.69), and anemia at term (RR 0.27; 95% CI: 0.12 to 0.56), respectively.…”

Section: Iron-folic Acid Supplementationmentioning

confidence: 99%

The interconnections between maternal and newborn health – evidence and implications for policy

Lassi

Majeed

Rashid

et al. 2013

The Journal of Maternal-Fetal & Neonatal Medicine

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The past decade has witnessed increasing global attention and political support for maternal, newborn and child health. Despite this increased attention, actual progress has been slow and sporadic: coverage of key maternal and newborn health interventions remains low and there are wide disparities in access to care, within and across countries. Strategies for improving maternal and newborn health are closely linked, and can be delivered most effectively through a continuum of care approach. While these interventions are largely known, there is little information on which interventions have a positive health impact for both women and newborns. This supplement identifies the interventions during the preconception, pregnancy, intrapartum and postnatal periods found to have a positive, synergistic effect on maternal and neonatal outcomes. These interventions are then grouped into packages of care for delivery at the community, health center or hospital levels.

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“…In maternal blood, malaria parasites induce immune response, which results in the secretion of cytokines (Prema et al, 1982). Similarly, semi-allogenic foetal tissue is directly exposed to the maternal blood which incidentally invades the maternal decidua and results in the activation and alteration of immune system of the mother with the secretion of cytokines (Lashley et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Peripheral Parasitaemia and Its Association With Plasma Cytokines Levels in Malaria-Infected Pregnant Women in Aba, Abia State, Nigeria

Ifeanyichukwu

Okamgba

Amilo

et al. 2017

AJID

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Background: Cytokines in pregnant female may not be a normal phenomenon as malarial infection is often associated with strong CD4+ cell activation and up-regulation of pro-inflammatory cytokines. We investigated the relationship between peripheral parasitaemia and plasma levels of cytokines among malaria infected pregnant women in Aba, Abia State, Nigeria. Materials and Methods: A total of 206 non-HIV positive asymptomatic malaria parasitaemic (n=144) and non-parasitaemic (n=62) pregnant women were recruited for this study alongside 80 non-pregnant women who served as positive (n=40) and negative (n=40) controls. Blood samples were aseptically collected from each subject and tested for HIV and malaria parasites using standard methods. Also, plasma levels of cytokines were measured using Th1/Th2 human cytokine ELISA kits (Abcam, UK). Analysis of Variance and Student's t-test were used for Comparison of groups while Pearson's Correlation Coefficient was used for tests of association. Results:The results revealed a mean parasite density of 685.56±484.55 parasites/µl of blood. Malaria infected pregnant subjects showed significantly higher levels of IFN-γ, TNF-α, IL-4, IL-6 and IL-10 when compared with their non-infected counterparts (P< 0.05). The cytokines evaluated were higher in moderate parasitaemia than mild parasitaemia. Positive correlation existed between peripheral parasite density (PPD) and IL-4 (r= 0.24, P=0.004), PPD and IL-6 (r = 0.35, P = 0.001) as well as PPD and IL-10 (r = 0.29, P = 0.001). Conclusion:This study showed that increase in peripheral parasitaemia increased levels of some plasma cytokines (IL-4, IL-6 and IL-10) but not IFN-γ and TNF-α in the malaria infected pregnant women studied.

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Immune status of anaemic pregnant women

Cited by 40 publications

References 15 publications

Sorologia positiva para sífilis, toxoplasmose e doença de Chagas em gestantes de primeira consulta em centros de saúde de área metropolitana, Brasil

Sorologia positiva para sífilis, toxoplasmose e doença de Chagas em gestantes de primeira consulta em centros de saúde de área metropolitana, Brasil

The interconnections between maternal and newborn health – evidence and implications for policy

Peripheral Parasitaemia and Its Association With Plasma Cytokines Levels in Malaria-Infected Pregnant Women in Aba, Abia State, Nigeria

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