Immune Responses in Myeloma

Linton, Alexander; Dunnigan, M. G.; Thomson, J.

doi:10.1136/bmj.2.5349.86

Cited by 12 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with malignant paraproteinemia the with low paraprotein levels (1,9,14,22). high incidence of bacterial infections has been Another point of interest is whether the polyascribed to a defective antibody response, as clonal immunoglobulin levels, which can be shown by the response to test antigens (2, 6, low or in the low normal range in these pa- 8,12,15,16). In patients with asymptomatic tients (1,3,9), reflect the humoral immune paraproteinemia data about the susceptibility to capacity.…”

mentioning

confidence: 99%

Immune Response in Asymptomatic Paraproteinemia

et al. 1976

View full text Add to dashboard Cite

In a group of 20 patients with asymptomatic paraproteinemia, as judged after at least 3 years of follow‐up, the primary and secondary antibody response to Helix pomatia hemocyanin (HPH) was defective as compared with the response in controls. The class of antibody was assessed by mercaptoethanol (ME) treatment of serum. A lowered response was found not only in the total but also in the ME‐resistant (mainly 7S, IgG) antibody titer. Low anti‐HPH antibody titers were preferentially found in the patients with high serum paraprotein levels, whereas in half of the patients with low serum paraprotein levels a completely normal antibody response was found. No differences in the total or 7S anti‐HPH antibody response were found between patients with IgG, IgM, or IgA paraproteinemia. The polyclonal serum Ig levels were not predictive for the measured anti‐HPH response. The anamnestic diphtheria and tetanus antibody response was not different from that of controls.

show abstract