“…However, they are in accord with several historical papers Table 3. published on vaccination against furunculosis. In spite of the successful pioneer oral vaccination experiment by Du# (1942), several authors subsequently failed to protect fish by the oral route (Snieszko & Friddle, 1949;Krantz et al, 1964;Spence et al, 1965;Klontz & Anderson, 1970;Hara et al, 1976;Udey & Fryer, 1978). Protection reported after immersion vaccination against furunculosis has been low to moderate Adams et al, 1988) or has been obtained in field experiments where the challenge was low (Palmer & Smith, 1980;Rodgers, 1990).…”