Immune response of 23‐valent pneumococcal polysaccharide vaccinated elderly and its relation to frailty indices, nutritional status, and serum zinc levels

Hamza, Sarah A.; Mousa, Shereen M.; Taha, Sherif M.; Adel, Lamiaa; Samaha, Hanan E.; Hussein, Dalia A

doi:10.1111/j.1447-0594.2011.00749.x

Cited by 24 publications

(10 citation statements)

References 30 publications

(54 reference statements)

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“…Zn deficiency also predisposed to impaired immune response to Pneumococcal surface protein A, increased nasal S. pneumoniae colonization, and severe pneumococcal infection in mice (133) resulting in shorter survival time after infection (134). correspondingly, patients with better immune response to 23-valent pneumococcal polysaccharide vaccine were characterized by significantly higher serum Zn levels (135). However, no effect (136) or serotype-specific effect (137) of Zn on antibody production in response to polyvalent pneumococcal vaccine was observed.…”

Section: Zinc and S Pneumoniae Infectionmentioning

confidence: 99%

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

et al. 2020

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Section: Zinc and S Pneumoniae Infectionmentioning

confidence: 99%

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

et al. 2020

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“…On the other hand, 4 wk after vaccination with the 23-valent pneumococcal polysaccharide vaccine, elderly individuals with a 10% increase in immunoglobulin M (IgM) memory B cells showed higher serum Zn levels compared to those with an immune response <10% of increase in IgM memory B cells (12). It has been suggested that Zn supplementation may influence the antibody response to immunization, even in those individuals presenting normal Zn plasma levels prior to the supplementation (29,30).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, on HIV-positive and in drug addict subjects, Zn supplementation (300 mg/day for 6 days) did not affect the immune response to the 7-valent pneumococcal conjugate vaccine (11). On the other hand, Zn serum deficiency impaired the immune response of 23-valent pneumococcal polysaccharide vaccine, analyzed by the level of immunoglobulin M memory B cell before and 4 wk after vaccination in elderly individuals (12).…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Supplementation on Serological Response to Vaccination AgainstStreptococcus Pneumoniaein Patients Undergoing Chemotherapy for Colorectal Cancer

Braga

Santos

Palmeira

et al. 2015

Nutrition and Cancer

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The aim of the study was to evaluate the effect of zinc supplementation on the antibody titer and the 23-valent pneumococcal seroconversion after vaccination in patients undergoing chemotherapy for colorectal cancer. The study included 25 patients undergoing postsurgery chemotherapy for colorectal adenocarcinoma (chemo group). Subjects were assessed in the perioperative period (prevaccination), before chemotherapy (4th wk) and after 3 cycles of chemotherapy (16th wk). Thirty-two healthy volunteers (control group) were included in the study. Participants received the 23-valent pneumococcal conjugate vaccine, and capsules containing zinc (Zn) sulfate (70 mg daily) or identical placebo capsules (containing wheat starch with no added Zn) for 16 wk and were randomly allocated on one of the following groups: chemo-Zn (n = 10), chemo-placebo (n = 15), control-Zn (n = 21), and control-placebo (n = 11). The antipneumococcal antibody titer against 6 polysaccharides was analyzed by ELISA and compared using linear mixed models. The seroconversion rate was compared using Fisher's exact test. An immune response to the vaccination against pneumococcus was observed in all participants. In the 16th wk, the polysaccharide 6 concentration was lower in the chemo-Zn group [2.96 (1.74-5.03) μg/mL] compared with the Chemo-Placebo group [10.75 (5.37-21.54) μg/mL] and the seroconversion rate was lower in the chemo-placebo (36%) compared with the control-placebo (85%) (P = 0.027). Zinc supplementation did not change the antibody titer after vaccination. However, the lower seroconversion rate observed in the chemo-placebo suggests an influence of zinc in the vaccinal protection.

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“…45 Next, the likelihood of confounding due to nutritional status, organ function, or subsequent medications upon immune response was not addressed. 46 This is because the sample size was too small to permit the use of a multivariable regression model. 47 These co-morbid factors may confound any association between host immunity and survival, and would be expected to result in bias away from the null.…”

Section: Discussionmentioning

confidence: 99%

Phase II Trial of a GM-CSF-producing and CD40L-expressing Bystander Cell Line Combined With an Allogeneic Tumor Cell–based Vaccine for Refractory Lung Adenocarcinoma

Creelan

Antonia

Noyes

et al. 2013

Journal of Immunotherapy

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We created a vaccine in which irradiated allogeneic lung adenocarcinoma cells are combined with a bystander K562 cell line transfected with hCD40L and hGM-CSF. By recruiting and activating dendritic cells, we hypothesized that the vaccine would induce tumor regression in metastatic lung adenocarcinoma. Intradermal vaccine was given q14 days x3, followed by monthly x3. Cyclophosphamide (300 mg/m2 IV) was administered before the 1st and 4th vaccines to deplete regulatory T-cells. All-trans retinoic acid was given (150/mg/m2/day) after the 1st and 4th vaccines to enhance dendritic cell differentiation. Twenty-four participants were accrued at a single institution from 10/2006 to 6/2008, with a median age 64 and median of 4 previous lines of systemic therapy. A total of 101 vaccines were administered. Common toxicities were headache (54%) and site reaction (38%). No radiologic responses were observed. Median overall survival (OS) was 7.9 months (mo) and median progression-free survival (PFS) was 1.7 mo. Of 14 patients evaluable for immunological study, 5 had peptide-induced CD8+ T-cell activation after vaccination. Overall, vaccine administration was feasible in an extensively pretreated population of metastatic lung cancer. Despite a suggestion of clinical activity in the subset with immune response, the trial did not meet the primary endpoint of inducing radiologic tumor regression.

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Immune response of 23‐valent pneumococcal polysaccharide vaccinated elderly and its relation to frailty indices, nutritional status, and serum zinc levels

Abstract: Poor nutritional status, frailty and a lower zinc level impair the immunological response of elderly individuals.

Cited by 24 publications

References 30 publications

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

Effect of Zinc Supplementation on Serological Response to Vaccination AgainstStreptococcus Pneumoniaein Patients Undergoing Chemotherapy for Colorectal Cancer

Phase II Trial of a GM-CSF-producing and CD40L-expressing Bystander Cell Line Combined With an Allogeneic Tumor Cell–based Vaccine for Refractory Lung Adenocarcinoma

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