Immune Response in Goats to Two Commercial Foot-and-Mouth Disease Vaccines and the Assessment of Maternal Immunity in Their Kids

Madhanmohan, M.; Tresamol, P. V.; Saseendranath, M. R.

doi:10.1111/j.1865-1682.2008.01056.x

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…In all the three groups maternally derived antibodies (MDA) remained at protective level (PI value >50) upto the age of 22-23 wks and decreased below protective level (PI value <50) at 27-28 weeks (above 6 months) of age. This findings support the finding of Madhanmohan et al (2009), who stated that MDA titers are likely to persist for 4-5 months of age in calves. Periolo et al (1993) and Auge de Mello et al (1989) also opined that young calves are the mandatory candidate for FMD vaccination at 4-5 months after birth when they lose passive immunity.…”

Section: Resultssupporting

confidence: 92%

“…In countries like Bangladesh the containment and control of FMD relies predominantly on vaccination. Calves bore to vaccinated cows usually possess maternal antibodies against FMDV in their serum for 2-6 months (Shankar and Uppal, 1982;Madhanmohan et al, 2009). This maternally derived antibody (MDA) provides immediate protection against infection with FMD virus, but also interferes with the development of active immunity following vaccination (Kitching and Salt, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Persistence of Maternally Derived Antibodies in Calves to Vaccination Against Foot and Mouth Disease

Akhter

Ms²,

Uddin³

et al. 2016

Bangl. J. Vet. Med.

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This study aimed to know the level of maternally derived antibody (MDA) titer in calves born to cows vaccinated with inactivated trivalent (type O, A and Asia 1) Foot and Mouth disease vaccine. Three groups of calves (10 calves in each group) of different age were randomly selected from two organized farms from Savar Upazilla of Bangladesh where the dams are routinely vaccinated with trivalent FMD vaccines. Blood samples were collected from these selected calves in six occasions five weeks apart and sera (n=180) were tested for antibody titer against FMDV by using liquid phase blocking ELISA (LPB-ELISA) test. The test is based upon specific blocking of the FMDV antigen in liquid phase by antibodies in the test serum sample. Protective level (PI value >50) of maternal antibody against FMDV was found in serum of calves up to the age of 22-23 wks (above five months) and decreased below protective level (PI value <50) at 27-28 weeks (above 6 months) of age. Irrespective of vaccine types, male calves had slightly higher level of MDA than that of female calves and PI values were comparatively higher against serotype O than the other two serotypes (A and Asia 1). Calves born to vaccinated dams could be vaccinated for first time after five months of their birth to lower the incidence of foot and mouth disease.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Persistence of Maternally Derived Antibodies in Calves to Vaccination Against Foot and Mouth Disease

Akhter

Ms²,

Uddin³

et al. 2016

Bangl. J. Vet. Med.

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“…All the ruminants are affected and the disease has been studied extensively in cattle, less so in buffaloes and sheep but poorly in goats. Vaccination of goats results in protective immune response and development of colostral antibodies [1]. Small ruminants are vaccinated only in the face of FMD outbreak and vaccination programs do not include small ruminants.…”

Section: Introductionmentioning

confidence: 99%

Immune Response in Goats to Different Payloads of FMDV Monovalent Vaccine: Protection Against Virulent Challenge and Development of Carrier Status

et al. 2011

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The relationship of Foot-and-Mouth Disease virus antigen payload and number of dose of vaccine conferring protection against virus challenge in goats was studied. Goats vaccinated with oil adjuvant Foot-and-Mouth Disease vaccines containing different antigen payloads with or without booster resisted virulent challenge at 21 days post-vaccination or 7 days after booster respectively. However, localized sub-clinical infection was observed in two vaccinated goats on 35 days post-challenge. RNA could be detected from 31.8% of vaccinated goats (10(2.69)-10(4.99) viral RNA copies per cotton swab of nasal secretions) on day 35 post-challenge. Since no live virus could be isolated after 5 days post-challenge, the risk of these animals transmitting the disease was probably very low. The finding showed that oil adjuvant Foot-and-Mouth Disease vaccines containing antigen payload of 1.88 μg may prevent or reduce the local virus replication at the oropharynx and shedding of virus from nasal secretions and thereby reduce the amount of virus released into the environment subsequent to exposure to live virus. This study also showed that goats with poor sero conversion to vaccination can be infected without overt clinical signs and became carriers like sheep.

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“…India constitutes around 148.88 million heads of goat population and 74.26 million heads of sheep population in the world. Moreover, cattle, buffalo, sheep and goats are grazed together in India (5). FMD outbreaks in sheep and goats are reported in India (6,7).…”

Section: Introductionmentioning

confidence: 99%

Experimental Infection of Foot and Mouth Disease in Indian Sheep and Goats

2020

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Foot-and-mouth disease (FMD) is an economically important contagious disease of livestock mainly cattle, buffalo, sheep, goats, and pig. There is limited data available on pathogenesis of foot and mouth disease in goats. In the study, the sheep and goats were infected experimentally with a serotype O foot-and-mouth disease virus by different challenge routes. The sheep and goats challenged by coronary band route and coronary band and intra-dermo-lingual route exhibited FMD clinical signs at 2-5 days post challenge. Whereas intra-dermo-lingual challenged sheep and goats did not exhibit FMD clinical signs. Live virus could be isolated from blood of infected sheep and goats at 2-5 days post challenge. Viral RNA could be detected from blood of infected sheep and goats at 1-10 days post challenge. The neutralizing antibody titre was detected at 10 days post challenge and maintained up to 35 days post challenge in all infected sheep and goats. Non structural protein (NSP) antibodies were detected as early as 5-10 days post challenge and remain positive up to 35 days post challenge in the infected sheep and goats. In conclusion, the pathogenesis of sheep and goats with serotype O foot and mouth disease virus by different challenge routes could be demonstrated.

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Immune Response in Goats to Two Commercial Foot-and-Mouth Disease Vaccines and the Assessment of Maternal Immunity in Their Kids

Cited by 12 publications

References 6 publications

Persistence of Maternally Derived Antibodies in Calves to Vaccination Against Foot and Mouth Disease

Persistence of Maternally Derived Antibodies in Calves to Vaccination Against Foot and Mouth Disease

Immune Response in Goats to Different Payloads of FMDV Monovalent Vaccine: Protection Against Virulent Challenge and Development of Carrier Status

Experimental Infection of Foot and Mouth Disease in Indian Sheep and Goats

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