Persistence of Maternally Derived Antibodies in Calves to Vaccination Against Foot and Mouth Disease

Abstract

This study aimed to know the level of maternally derived antibody (MDA) titer in calves born to cows vaccinated with inactivated trivalent (type O, A and Asia 1) Foot and Mouth disease vaccine. Three groups of calves (10 calves in each group) of different age were randomly selected from two organized farms from Savar Upazilla of Bangladesh where the dams are routinely vaccinated with trivalent FMD vaccines. Blood samples were collected from these selected calves in six occasions five weeks apart and sera (n=180) were tested for antibody titer against FMDV by using liquid phase blocking ELISA (LPB-ELISA) test. The test is based upon specific blocking of the FMDV antigen in liquid phase by antibodies in the test serum sample. Protective level (PI value >50) of maternal antibody against FMDV was found in serum of calves up to the age of 22-23 wks (above five months) and decreased below protective level (PI value <50) at 27-28 weeks (above 6 months) of age. Irrespective of vaccine types, male calves had slightly higher level of MDA than that of female calves and PI values were comparatively higher against serotype O than the other two serotypes (A and Asia 1). Calves born to vaccinated dams could be vaccinated for first time after five months of their birth to lower the incidence of foot and mouth disease.

Persistence of Maternal Antibodies Against Foot-and-Mouth-Disease Virus in Colostrum Fed Calves Born from FMD Convalescent Vaccinated Dams Under Natural Conditions

“…Therefore, the presence of anti-NSP antibodies as well as anti-SP antibodies for FMD virus serotypes 'O,' ' A,' and ' Asia1' in these calves suggests the passive transfer of maternal antibodies via colostrum from immunised dams to their calves. Previous research has shown that maternal antibodies can survive in calves for up to two months after birth [16,17], whereas Akhter., et al [18] found MDA in calves' serum up to the age of 22-23 weeks. The immune response of newborn calves to FMDV depends on vaccine formulation and may or may not be dependent on maternal antibodies [6,7].…”

The estimation of duration of maternally-derived antibodies against Akabane, Aino, and Chuzan virus in calves by the receiver operating characteristic analysis

“…Besides, the maternally-derived antibodies against respiratory viruses were believed to be kept for 4–6 months for bovine viral diarrhea virus (BVDV)−1, 3–6 months for BVDV-2, 5–7 months for bovine respiratory syncytial virus, 2–4 months for bovine herpesvirus-1, and 5–6 months for bovine parainfluenza virus-3 [ 4 , 9 , 10 ]. The maternally-derived antibodies against foot and mouth disease virus decreased below the protective level at 27–28 weeks (above 6 months) of age [ 2 ]. Although the longevity of the duration of maternally-derived antibodies varied in each virus, it was assumed that the maternally-derived antibodies against a virus are substantially maintained for 4–7 months in a calf.…”