Immune Response and Pasteurella Resistance in Rabbits Fed Diets Containing Various Amounts of Black Cumin Seeds

El-Bagir, N. M.; Farah, I. T. O.; ElHag, Somayia; Alhaidary, A.; Mohamed, H. E.; Beynen, A.C.

doi:10.3844/ajavsp.2010.163.167

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…In addition, quarter location, lnSCCpre and the interaction of parity with lnSCCpre and quarter location were significantly associated with lnSCCpost (El Bagir et al, 2010;Mungube et al, 2005).…”

Section: Discussionmentioning

confidence: 94%

Comparison of Two Regimens of Nigella sativa Extract for Treatment of Subclinical Mastitis Caused by Staphylococcus aureus

Azadi¹,

Farzaneh²

2010

American Journal of Applied Sciences

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Problem statement: Little research has focused on treatment of cows with subclinical mastitis during lactation. The seed of Nigella sativa Linn. (Ranunculaceae), commonly known as black seed or black cumin, is used in folk (herbal) medicine. Approach: Objectives of this study were to evaluate the effect of Nigella sativa Extract (NSE) with two regimens for treatment of subclinical mastitis in lactating dairy cows and to determine which regimen enhanced efficacy of it. Results: From one hundred Holstein dairy research herd in Mashhad-Iran, 83 cows with a total of 157 subclinically Staphylococcus aureus infected quarters were included. Cows were enrolled in the study based on milk somatic cell counts >200,000 mL −1 and isolation of Staphylococcus aureus in 3 samples obtained 1 week apart. About 10 cc of NSE (in paraffin: 200 mg cc −1 ) was administered via intramammary infusion. First, Cows were divided into three treatment groups. Group 1 (37 cows) received intramammary infusion at each milking (3 times daily) for 3 days with 10 cc NSE. Group 2 (24 cows) received the same intramammary infusion but only once daily for 3 days. The third, 22 cows were included as an untreated negative control group. Results in bacteriologic cure of 69.4% of quarters and 59.5% of cows (Group 1) compared to 60% of quarters and 45.8% of cows (Group 2). Test for mastitis diagnosis Somatic cell counts of milk from quarters that were not cured were higher prior to initiation of treatment than those cured. A bacteriological cure was defined as a treated infected mammary quarter that was bacteriologically negative for the presence of S. aureus at 3-7 day after the last treatment. Conclusion: All two Nigella sativa treatment regimens were significantly better than the negative control and the nine dose Nigella sativa treatment regimen treatment group was not significantly better than the three dose treatment group (p = 0.332).

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Section: Discussionmentioning

confidence: 94%

Comparison of Two Regimens of Nigella sativa Extract for Treatment of Subclinical Mastitis Caused by Staphylococcus aureus

Azadi¹,

Farzaneh²

2010

American Journal of Applied Sciences

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“…Moreover, boosted immune reactions in broiler chickens were achieved after dietary inclusion of black cumin ( Nigella sativa L.) powder [ 58 ]. In a comparable study, feeding of rabbits on diets containing black cumin seed greatly modulated their immune responses [ 59 ]. Similarly, dietary supplementation with N. sativa in male Wistar rats mediated immunological function [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa Extract Potentially Inhibited Methicillin Resistant Staphylococcus aureus Induced Infection in Rabbits: Potential Immunomodulatory and Growth Promoting Properties

Elmowalid

Ahmad

El-Hamid

et al. 2022

Animals

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Weaning is the most crucial period associated with increased stress and susceptibility to diseases in rabbits. Methicillin-resistant Staphylococcus aureus (MRSA), a historic emergent pathogen related to post weaning stressors, adversely affects rabbit’s growth rate and productive cycle. Since MRSA is rapidly evolving antibiotics resistance, natural products are desperately required to tackle the public health threats posed by antimicrobial resistance. Thus, this study aimed to screen the in vitro antibacterial activity of Nigella sativa extract (NSE) and its interactions with antibiotics against MRSA isolates. Moreover, 200 weaned rabbits were divided into 4 groups to investigate the in vivo superiority of NSE graded levels towards growth performance, tight junction integrity, immune responsiveness and resistance against MRSA. Herein, NSE showed promising antimicrobial activities against MRSA isolates from animal (77.8%) and human (64.3%) origins. Additionally, MRSA isolates exposed to NSE became sensitive to all antimicrobials to which they were previously resistant. Our results described that the growth-promoting functions of NSE, especially at higher levels, were supported by elevated activities of digestive linked enzymes. Post-NSE feeding, rabbits’ sera mediated bactericidal activities against MRSA. Notably, upregulated expression of occludin, CLDN-1, MUC-2 and JAM-2 genes was noted post NSE supplementation with maximum transcriptional levels in 500 mg/kg NSE fed group. Our data described that NSE constitutively motivated rabbits’ immune responses and protected them against MRSA-induced experimental infection. Our results suggest the antimicrobial, growth stimulating and immunomodulation activities of NSE to maximize the capability of rabbits for disease response.

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Herbs and spices inclusion as feedstuff or additive in growing rabbit diets and as additive in rabbit meat: A review

2016

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Immune Response and Pasteurella Resistance in Rabbits Fed Diets Containing Various Amounts of Black Cumin Seeds

Cited by 5 publications

References 20 publications

Comparison of Two Regimens of Nigella sativa Extract for Treatment of Subclinical Mastitis Caused by Staphylococcus aureus

Comparison of Two Regimens of Nigella sativa Extract for Treatment of Subclinical Mastitis Caused by Staphylococcus aureus

Nigella sativa Extract Potentially Inhibited Methicillin Resistant Staphylococcus aureus Induced Infection in Rabbits: Potential Immunomodulatory and Growth Promoting Properties

Herbs and spices inclusion as feedstuff or additive in growing rabbit diets and as additive in rabbit meat: A review

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