Immune‐related <scp>microRNAs</scp> in breast milk and their relation to regulatory T cells in breastfed children

Ahlberg, Emelie; Martí, Magalí; Govindaraj, Dhanapal; Severin, Elisabet; Duchén, Karel; Jenmalm, Maria C.; Tingö, Lina

doi:10.1111/pai.13952

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…One study hypothesized that miRNAs in breast milk may be involved in immune regulation, based on which to explore whether L. reuteri has a role in miRNA expression. The results showed that miRNA did affect the number of resting Treg cells and activated Treg cells in infants, but L. reuteri did not affect miRNAs expression ( 54 ). Studies have shown that prenatal supplementation with L. reuteri induced hypomethylation of CD4 + T-cells DNA.…”

Section: Immune Regulation Mechanismmentioning

confidence: 99%

Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications

et al. 2023

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Frequent use of hormones and drugs may be associated with side-effects. Recent studies have shown that probiotics have effects on the prevention and treatment of immune-related diseases. Limosilactobacillus reuteri (L. reuteri) had regulatory effects on intestinal microbiota, host epithelial cells, immune cells, cytokines, antibodies (Ab), toll-like receptors (TLRs), tryptophan (Try) metabolism, antioxidant enzymes, and expression of related genes, and exhibits antibacterial and anti-inflammatory effects, leading to alleviation of disease symptoms. Although the specific composition of the cell-free supernatant (CFS) of L. reuteri has not been clarified, its efficacy in animal models has drawn increased attention to its potential use. This review summarizes the effects of L. reuteri on intestinal flora and immune regulation, and discusses the feasibility of its application in atopic dermatitis (AD), asthma, necrotizing enterocolitis (NEC), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS), and provides insights for the prevention and treatment of immune-related diseases.

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Section: Immune Regulation Mechanismmentioning

confidence: 99%

Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications

et al. 2023

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“…We highlight here as editor's choice the recent study by Ahlbers et al which postulated that the expression of immune‐related miRNAs in breast milk is influenced by pre‐ and postnatal supplementation with Limosilactobacillus reuteri and omega‐3 polyunsaturated fatty acids through immunomodulation by infant's regulatory T cells 8 . miRNA are small noncoding RNAs that can modulate gene expression on a posttranscriptional level.…”

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confidence: 99%

Editorial comments on: “Immune‐related microRNAs in breast milk and their relation to regulatory T cells in breastfed children”

Eigenmann

Santos

2023

Pediatric Allergy Immunology

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Editorial comments on: "Immune-related microRNAs in breast milk and their relation to regulatory T cells in breastfed children"Primary prevention is an area of wide interest for the prevention of allergies, with early-life interventions yielding a high potential of intervention. Various strategies have investigated dietary interventions during pregnancy, or earlylife feeding patterns, however, with variable levels of efficiency. 1,2 Among these, lactation with human breast milk finds is widely supported due to its many beneficial aspects; however, controversy still remains about whether breastfeeding can prevent the development of allergic disease. 3 In the quest of deciphering the beneficial mechanisms behind the potential preventive effect of breast milk, various authors have recently evoked the role of metabolites such as caprylate or acetate, 4 or of modulation of IgA levels, 5 but also potentially of micro-RNAs and the gut microbiome. 6,7 We highlight here as editor's choice the recent study by Ahlbers et al. which postulated that the expression of immune-related miRNAs in breast milk is influenced by pre-and postnatal supplementation with Limosilactobacillus reuteri and omega-3 polyunsaturated fatty acids through immunomodulation by infant's regulatory T cells. 8 miRNA are small noncoding RNAs that can modulate gene expression on a posttranscriptional level. In breast milk, they are encapsulated in extracellular vesicles and might be involved in immunomodulatory pathways, for example, in the development and maturation of T cells. Breast milk was collected from mothers with a history of allergic diseases enrolled in a randomized controlled trial to receive Limosilactobacillus reuteri with or without omega-3 polyunsaturated fatty acids. Infant blood was collected at 6, 12, and 24 months and analyzed for regulatory T-cell subpopulations.

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MicroRNA as a new bioactive component in breast milk

Słyk-Gulewska,

Kondracka,

Kwaśniewska

2023

Non-coding RNA Research

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Immune‐related microRNAs in breast milk and their relation to regulatory T cells in breastfed children

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 48 publications

Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications

Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications

Editorial comments on: “Immune‐related microRNAs in breast milk and their relation to regulatory T cells in breastfed children”

MicroRNA as a new bioactive component in breast milk

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