MicroRNA as a new bioactive component in breast milk

Słyk-Gulewska, Patrycja; Kondracka, Adrianna; Kwaśniewska, Anna

doi:10.1016/j.ncrna.2023.06.003

Cited by 11 publications

(7 citation statements)

References 54 publications

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“…The composition of miRNAs in human breast milk varies depending on factors such as gestational age at delivery and lactation stage, with preterm milk exhibiting distinct miRNA profiles compared to term milk. Changes in miRNA expression patterns in preterm milk may reflect adaptations to promote neurodevelopment and mitigate the challenges faced by preterm infants, contributing to the maturation of the preterm infant’s brain ( Slyk-Gulewska et al ., 2023 ).…”

Section: Exosomes In Breast Milkmentioning

confidence: 99%

“…Research indicates that while the total concentration of miRNAs remains relatively stable during the first 6 months of lactation, significant changes occur in miRNA composition, particularly at 4 months compared to 2 months postpartum, suggesting an adaptation of miRNA profiles to meet the evolving needs of the infant. Additionally, mothers who deliver prematurely exhibit altered hormonal profiles and miRNA expression in their breast milk, potentially benefiting premature infants by influencing glucose homeostasis, adipogenesis, and immune function ( Slyk-Gulewska et al ., 2023 ).…”

Section: Exosomes In Breast Milkmentioning

confidence: 99%

“…The delivery method also impacts miRNA expression in breast milk, with cesarean delivery disrupting the balance of specific miRNAs and potentially increasing the risk of type 2 diabetes mellitus (T2DM) later in life ( Slyk-Gulewska et al ., 2023 ). Furthermore, correlations between maternal stress levels and changes in extracellular vesicle-derived miRNAs suggest potential impacts on fatty acid metabolism, steroid biosynthesis, and organ growth regulation in infants.…”

Section: Exosomes In Breast Milkmentioning

confidence: 99%

“…Understanding the diverse roles of miRNAs in breast milk and their modulation by various factors holds promise for the prevention and treatment of various diseases in infants, including necrotizing enterocolitis (NEC), atopic diseases, diabetes, obesity, and cancer. Further research is imperative to elucidate the specific mechanisms and therapeutic potential of miRNAs in breast milk ( Slyk-Gulewska et al ., 2023 ).…”

Section: Exosomes In Breast Milkmentioning

confidence: 99%

“…Growth factors carried by exosomes may contribute to the development and maturation of the infant’s gastrointestinal tract and other tissues. Exosomes may play a role in shaping the infant’s gut microbiota, which has a significant impact on overall health ( Slyk-Gulewska et al ., 2023 ).…”

Section: Exosomes In Breast Milkmentioning

confidence: 99%

See 4 more Smart Citations

Fingerprinting Breast Milk; insights into Milk Exosomics

Papakonstantinou,

Dragoumani,

Mataragka

et al. 2024

EMBnet j.

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Breast milk, often referred to as "liquid gold," is a complex biofluid that provides essential nutrients, immune factors, and developmental cues for newborns. Recent advancements in the field of exosome research have shed light on the critical role of exosomes in breast milk. Exosomes are nanosized vesicles that carry bioactive molecules, including proteins, lipids, nucleic acids, and miRNAs. These tiny messengers play a vital role in intercellular communication and are now being recognized as key players in infant health and development. This paper explores the emerging field of milk exosomics, emphasizing the potential of exosome fingerprinting to uncover valuable insights into the composition and function of breast milk. By deciphering the exosomal cargo, we can gain a deeper understanding of how breast milk influences neonatal health and may even pave the way for personalized nutrition strategies.

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Section: Exosomes In Breast Milkmentioning

confidence: 99%

Section: Exosomes In Breast Milkmentioning

confidence: 99%

Section: Exosomes In Breast Milkmentioning

confidence: 99%

Section: Exosomes In Breast Milkmentioning

confidence: 99%

Section: Exosomes In Breast Milkmentioning

confidence: 99%

See 3 more Smart Citations

Fingerprinting Breast Milk; insights into Milk Exosomics

Papakonstantinou,

Dragoumani,

Mataragka

et al. 2024

EMBnet j.

View full text Add to dashboard Cite

show abstract

Milk‐derived exosomes in the regulation of nutritional and immune functions

Yang,

Wuren,

Zhai

et al. 2024

Food Science & Nutrition

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Milk‐derived exosomes (MDEs), being a component of milk, have the potential to support immune system maturation in offspring and enhance immune cell proliferation. Through the transport and transmission of essential signaling molecules, MDEs contribute to the regulation of intergenerational and intraspecies communication, thereby impacting nutrient uptake and metabolic functions. A comprehensive comprehension of MDE functionalities is imperative for enhancing the quality of the dairy industry. A systematic search of the databases PubMed/Medline, Web of Science, and Scopus utilizing predetermined keywords resulted in the identification of 418 articles, of which 67 were chosen for inclusion in this review, which specifically explores the intersection of immune response and nutrition. This article provides a critical analysis of the classification of extracellular vesicles, the mechanisms underlying the biosynthesis of microvesicular dietary exosomes (MDEs), the components of MDEs, and their relevance in the contexts of nutrition and immune modulation. The primary aim of this review was to offer valuable scholarly insights to support the advancement and practical application of MDEs.

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Dysregulation of miR‐146a in human milk of mothers having children with autism

Meguid,

Hemimi,

Rashad

et al. 2024

Intl J of Devlp Neuroscience

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Autism spectrum disorder (ASD) is a set of neurobehavioral manifestations that impose poor social interaction and stereotyped repetitive patterns. Several mircoRNA (miRNA) dysregulations underpin ASD pathophysiology via impairing the neurogenic niches. For instance, miR‐146a and miR‐106 differential expressions are linked to deregulation of ASD‐related genes and the severity of clinical symptoms, respectively. Breastfeeding provides newborns with many bioactive compounds that support their neurodevelopment including miRNA. Our pilot study evaluated the expression pattern of miR‐106a and miR‐146a in human milk (HM) of nursing mothers (n = 36) having autistic children compared to age‐matched counterparts (n = 36) with neurotypical children as controls. Under sterile conditions, breast milk samples were collected using manual sucking pumps and centrifuged to separate the fat layer. Total RNA was extracted from the lipid fraction, and the expression profiles of both miR‐106a and miR‐146a were evaluated using quantitative real‐time polymerase chain reaction. Among the test group, we reported some factors that were previously linked to HM miRNA perturbations: gestational diabetes, hypertension, and cesarean delivery. HM miR‐106a showed comparable expression levels in both mother groups (p = 0.8681), whereas HM miR‐146a was significantly downregulated in mothers with autistic children compared to controls (p = 0.0399). Alternatively, HM miR‐106 levels were positively associated with two ASD clinical parameters: Childhood Autism Rating Scale (CARS) and communication and language domain of Autism Diagnostic Interview‐Revised (ADI‐R) (r = 0.6452, p = 0.0003 and r = 0.3958, p = 0.0410, respectively). The receiver operating characteristic (ROC) curves of both maternal HM miR‐106a and miR‐146a showed poor fitness as predictive biomarkers for ASD. Our findings suggest that the miR‐146a differential expression in ASD children may originate at infancy during the lactation period. Thus, maternal pre‐ and postnatal health care is critical to maintain optimal miRNome in breast milk.

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MicroRNA as a new bioactive component in breast milk

Cited by 11 publications

References 54 publications

Fingerprinting Breast Milk; insights into Milk Exosomics

Fingerprinting Breast Milk; insights into Milk Exosomics

Milk‐derived exosomes in the regulation of nutritional and immune functions

Dysregulation of miR‐146a in human milk of mothers having children with autism

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