Immune regulation mechanism of vitamin�D level and IL‑17/IL‑17R pathway in Crohn's disease

Xia, Yanli; Chen, Hongwei; Xiao, Haibin; Yang, Jing; Li, Zhibin; Wang, Youchun; Yang, Tian; Wang, Baoyong

doi:10.3892/etm.2019.7389

Cited by 6 publications

(7 citation statements)

References 24 publications

(30 reference statements)

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“…This was accompanied by lower levels of IL-17, IL17R, and Th17 cells in the colonic mucosa, suggesting that vitamin D may alleviate CD-induced inflammation by inhibiting the IL-17/IL-17R pathway, thus improving immune function and reducing disease severity. 87 Interestingly, a randomized controlled trial (RCT) showed that treating pregnant women with 2000 IU vitamin D daily can increase regulatory T cell immunity by enhancing the percentage of Treg and IL-10 + CD4 T cells in the peripheral blood. 88 In addition, vitamin D can enhance Treg function by increasing IL-10, TGF-β, FoxP3, and CTLA4 production thereby suppressing inflammation.…”

Section: Vitamin D and Ibd Pathogenesismentioning

confidence: 99%

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Wu¹,

Liu²,

Deng³

2022

JIR

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Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.

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Section: Vitamin D and Ibd Pathogenesismentioning

confidence: 99%

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Wu¹,

Liu²,

Deng³

2022

JIR

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“…Statistical analysis revealed a significant difference in IL-17 expression between the endometriosis mice model given vitamin D at a dose of 24 IU and mice not given treatment. At serum vitamin D levels greater than 20 ng/ml, vitamin D supplementation is known to regulate IL-17 and improve the profile of various autoimmune diseases ( Bruce et al, 2011 ; Joshi et al, 2011 ; Bhargava et al, 2015 ; Aly et al, 2017 ; Xia et al, 2019 ; Ghorbani et al, 2021 ; Mahmoud et al, 2021 ). Roffe-Vazquez et al (2019) discovered a negative relationship between serum vitamin D levels and IL-17A.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D immunomodulation of IL-17 can occur through a decrease in the number of IL-17-producing cells, inhibition of CD4+ T cell differentiation into Th17 cells, and a repressive effect on IL-17 expression ( Bruce et al, 2011 ; Joshi et al, 2011 ). The repressive effect is caused by the vitamin D receptor’s transcription suppression mechanism, which inhibits the Il-17/Il-17R pathway ( Joshi et al, 2011 ; Xia et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D has been reported to decrease the number of IL-17-producing cells, inhibit the differentiation of CD4+ T cells into Th17 cells, and repress IL-17 expression ( Bruce et al ., 2011 ; Joshi et al ., 2011 ). Although vitamin D is known to improve the profile of various autoimmune diseases, the effect of vitamin D on IL-17 expression in endometriosis has not been researched yet ( Bruce et al ., 2011 ; Joshi et al ., 2011 ; Bhargava et al ., 2015 ; Aly et al ., 2017 ; Xia et al ., 2019 ; Ghorbani et al ., 2021 ; Mahmoud et al ., 2021 ). Based on those studies, it can be extrapolated that Vitamin D can regulate IL-17 expression in endometriosis.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Burjiah¹,

adi²,

Widjiati³

2022

Open Vet J

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Background: Endometriosis is a common benign, estrogen-dependent, and chronic gynecological disease. Immune system disturbances and inflammatory abnormalities were involved in the pathogenesis of endometriosis. , Therefore, it is logical to use vitamin D, which has an immunomodulatory capacity, as supportive therapy for endometriosis. Aims: This research time to study the effect of different doses of vitamin D on IL-17 expression in endometriosis mice models. Methods: Endometriosis was induced in twenty-four mice divided into four groups of six. Group C received no treatment, while groups T1, T2, and T3 received graded doses of vitamin D to the stomach, sequentially 8 IU, 16 IU, and 24 IU for three weeks. Interleukin-17 expression and the extent of endometriotic peritoneal lesions were also measured and analyzed. Statistical tests were performed to see the difference in the mean area of endometriosis lesions and IL-17 expression between the control and treatment groups, as well as the correlation between the extent of endometriosis lesions and IL-17. We performed a statistical test to determine whether stratified doses have different IL-17 and endometriosis area outcomes. Results: The area of endometriosis lesions was decreased after 16 IU and 24 IU of vitamin D administration (p 0.023 and 0.009). Endometriosis lesions also tended to be smaller after 8 IU of vitamin D supplementation, although insignificant (p > 0.05). Interleukin-17 expression was significantly lower after 24 IU vitamin D administration (p = 0.004). Vitamin D doses of 8 IU and 16 IU caused lower IL-17 expression, although not significant (p = 0.452 and p = 0.645). The regulation of IL-17 expression was significantly dependent on the dose level of vitamin D with an optimal dose of 24 IU (p = 0.004). This dose also caused the smallest endometriosis lesion, although not optimal (p > 0.05). IL-17 expression was moderately and positively correlated with the extent of endometriosis lesions (p = 0.012, rho = 0.505). Conclusion: By modulating the expression of interleukin-17 in endometriotic lesions, vitamin D inhibits the development of endometriotic lesions in the endometriosis mice model. The optimal vitamin D dose in this study was 24 IU.

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“…An inverse relationship between Vit. D and IL-17 levels in other autoimmune diseases have also been reported [40,41], But so far, the exact mechanism of the relationship between the decrease in Vit. D levels and the increase in IL-17 levels in autoimmune diseases, especially rheumatoid arthritis, have not been determined.…”

Section: Discussionmentioning

confidence: 99%

Association of 25-Hydroxy Vitamin D with IL-17 Inflammatory Cytokines, and Osteoporosis in patients with Rheumatoid Arthritis in Kurdish nation / Iraq

Albarzinji¹,

Albustany²

2022

TORJ

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Introduction: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Lower Vitamin D (Vit. D) levels correlate with more severe clinical manifestations in RA and other rheumatic diseases. IL-17A promotes inflammation by inducing various proinflammatory cytokines and chemokines. In this study, we evaluated the association between Vitamin. D and IL-17 in osteoporosis in Rheumatoid Arthritis in Kurdish nation / Iraq. Objective: Blood samples from rheumatoid arthritis (RA) patients were used to measure the levels of the inflammatory cytokine IL-17 and the Vit. D precursor 25(OH)D and bone loss in patients with RA in this study. Methods: In this study, 40 healthy controls were included in the research, which comprised 100 new cases of RA. ELISA was used to measure the level of serum 25(OH)D and IL-17. Moreover, DXA was used to assess average bone mineral density (BMD). Results: We discovered no difference between the two groups in terms of age or gender. This means that compared to the control group, the 25(OH)D serum levels in the RA group were lower (P 0.01; 16.85+8.7 nmol/l vs. 39.95 (-+9.8)). IL-17 serum levels were highly and negatively associated with 25(OH)D levels in arthritic patients. A comparison of 25(OH)D levels in patients with osteoporosis and osteopenia and those with BMD was also performed. Conclusion: Bone loss and IL-17 have been associated with reduced Vit. D levels in patients with rheumatoid arthritis; a lack of Vit. D may have a role in developing the disease, according to the data presented in this study.

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Immune regulation mechanism of vitamin�D level and IL‑17/IL‑17R pathway in Crohn's disease

Cited by 6 publications

References 24 publications

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Association of 25-Hydroxy Vitamin D with IL-17 Inflammatory Cytokines, and Osteoporosis in patients with Rheumatoid Arthritis in Kurdish nation / Iraq

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