Immune Regulation by CD4+CD25+ regulatory T cells in Patients with Japanese Cedar Pollinosis

Allergen induced Treg response in the peripheral blood mononuclear cells (PBMCs) of patients with nasal polyposis

“…Thunberg et al demonstrated that CD4+CD25+ Treg cells from both allergic patients and controls could suppress the production of Th1 cytokines. 28 Yamanishi et al found that in pollenallergic patients, Treg cells predominantly suppressed Th1 responses rather than Th2 responses. 29 Our results showed that the IFN-γ level in supernatants of both atopic and non-atopic NP patients was significantly increased after allergen stimulation, indicating that impaired Tregs from NP patients fail to suppress not only Th2 but also Th1 cytokine production.…”

Staphylococcus aureus nasal colonization increases the risk of cedar pollinosis

“…3 Conversely, staphylococcal superantigens, such as TSST-1 and SEB, augment IgE response in atopic patients who are exposed to allergens specific to atopy. 7,8 These observations suggest that staphylococcal superantigens may also augment the onset of cedar pollinosis in a person subclinically sensitized by cedar pollen.If this were the case, the colonization of S. aureus in more than onethird of Japanese people 9,10 would contribute to an increase in the prevalence of cedar pollinosis.…”

“…Cumulative exposure to cedar pollen is the most important factor responsible for the induction of allergen‐specific Th2‐type responses 1,6–8 . However, even in cases where sensitization with Japanese cedar pollen is proven serologically, 50% of the people do not develop symptoms 3 .…”

“…However, even in cases where sensitization with Japanese cedar pollen is proven serologically, 50% of the people do not develop symptoms 3 . Conversely, staphylococcal superantigens, such as TSST‐1 and SEB, augment IgE response in atopic patients who are exposed to allergens specific to atopy 7,8 …”

“…[1][2][3][4][5] Cumulative exposure to cedar pollen is the most important factor responsible for the induction of allergen-specific Th2-type responses. 1,[6][7][8] However, even in cases where sensitization with Japanese cedar pollen is proven serologically, 50% of the people do not develop symptoms. 3 Conversely, staphylococcal superantigens, such as TSST-1 and SEB, augment IgE response in atopic patients who are exposed to allergens specific to atopy.…”