2012
DOI: 10.4103/1947-2714.97204
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Immune reactivity in psoriatic Munro-Saboureau microabscesses, stratum corneum and blood vessels

Abstract: Background:A characteristic feature of early active psoriatic lesions is the intraepidermal penetration of neutrophils, with attendant formation of Munro-Saboureau microabscesses. Previous immunofluorescence studies have shown reactivity of in vivo binding of stratum corneum antibodies (SCAs) within the Munro-Saboreau microabscesses in cases of psoriasis.Aims:In our study, we aimed to investigate any correlation between the SCAs and the Munro-Saboureau microabscesses.Materials and Methods:We investigated 50 ar… Show more

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Cited by 5 publications
(12 citation statements)
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References 26 publications
(25 reference statements)
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“…We found expression of RIBO, showing differential phosphorylation in distinct epidermal layers; the expression was most pronounced in hyperproliferative regions. Based on our previous [2,3], and current findings and those of others, differential S6 phosphorylation may play a role in abnormal keratinocyte proliferation/differentiation in psoriasis, although only a few cases have been documented [2,3,5]. A larger series of cases is needed to adequately study the role of RIBO in intracellular pathways in psoriasis patients.…”
Section: Discussionmentioning
confidence: 99%
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“…We found expression of RIBO, showing differential phosphorylation in distinct epidermal layers; the expression was most pronounced in hyperproliferative regions. Based on our previous [2,3], and current findings and those of others, differential S6 phosphorylation may play a role in abnormal keratinocyte proliferation/differentiation in psoriasis, although only a few cases have been documented [2,3,5]. A larger series of cases is needed to adequately study the role of RIBO in intracellular pathways in psoriasis patients.…”
Section: Discussionmentioning
confidence: 99%
“…Lesional skin was biopsied and studied utilizing hematoxylin and eosin (H&E) staining, as well as via IHC. All techniques were performed as previously described [2,3].…”
Section: Case Reportmentioning
confidence: 99%
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