Immune profiling of Alzheimer patients

Pellicanò, Mariavaleria; Larbi, Anis; Goldeck, David; Colonna‐Romano, Giuseppina; Buffa, Silvio; Bulati, Matteo; Rubino, Graziella; Iemolo, Francesco; Candore, Giuseppina; Caruso, Calogero; Derhovanessian, Evelyna; Pawelec, Graham

doi:10.1016/j.jneuroim.2011.11.005

Cited by 128 publications

(116 citation statements)

References 44 publications

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“…In addition, changes in lymphocyte subsets have been observed in patients with mild cognitive impairment and Alzheimer's disease. Patients with mild cognitive impairment or Alzheimer's disease showed lower percentages of B cells [28,47] but increased expansion of late-differentiated T cells (CD28-), especially in CD4+ cells [48,49,50]. These data are in line with our findings and give further support to the role of peripheral lymphocytes in human cognition.…”

Section: Discussionsupporting

confidence: 90%

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

Petersen

Grassi‐Oliveira

Siara

et al. 2014

Neuroimmunomodulation

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Background: Rheumatoid arthritis (RA) has been associated with premature immunosenescence and an increased prevalence of age-related morbidities including poor cognitive function. Objective: We explored the relationships among lymphocyte subsets and memory in RA. Methods: Thirty patients with RA and 19 age-matched healthy controls took part in this study. Cognitive function stress and depression scores were evaluated by structured clinical questionnaires. Lymphocytes were isolated and immunophenotyped by flow cytometry to investigate the following subsets: B cells, activated and naïve/memory T cells, regulatory FoxP3+ T (Treg) cells, Th17+ cells, NK cells and senescence-associated CD28- T cells. Results: RA patients were more depressed than controls, but stress levels were similar in the 2 groups. Patients had impaired memory performance compared to controls, demonstrated by lower Mini-Mental State Examination scores and logical and working memories (all p < 0.0001). These group effects remained significant after correcting for depression and age. Patients had expansion of regulatory T cells, naïve CD4+ T cells and CD8+CD28- cells but reduced percentages of B cells and memory CD8+CD45RO+ T cells compared to controls. CD8+CD28- and CD8+CD45RO+ T cells were found to be negatively associated with memory. Conclusion: RA patients had reduced memory performance compared to healthy controls. Expansion of activated and senescence-associated T cells was correlated with poor memory performance.

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Section: Discussionsupporting

confidence: 90%

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

Petersen

Grassi‐Oliveira

Siara

et al. 2014

Neuroimmunomodulation

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“…AD is also a systemic inflammatory disease and shows elevated Th1-mediated inflammation, which is similar to autoimmune diseases (D'Andrea, 2005;Pellicano et al, 2012). The similarity between AD and autoimmune diseases in immunology suggests there are certain similarities in epidemiology.…”

Section: Hygiene Hypothesis For Admentioning

confidence: 99%

Alzheimer’s disease and gut microbiota

Wang

Jin

2016

Sci. China Life Sci.

278

188

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“…Alzheimer (AD) and Parkinson (PD) diseases are age-related neurodegenerative conditions characterized by neuronal loss in hippocampus and substantia nigra, respectively. There are concepts supporting that AD and PD pathogenesis could be originally related to systemic immune system dysfunction (42). The frequency of NK cells seems unmodified in the blood of AD patients (43,44).…”

Section: Nk Cell Modifications Associated With Cns Disordersmentioning

confidence: 99%

NK Cells in Central Nervous System Disorders

Poli

Kmiecik

Domingues

et al. 2013

The Journal of Immunology

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NK cells are important players in immunity against pathogens and neoplasms. As a component of the innate immune system, they are one of the first effectors on sites of inflammation. Through their cytokine production capacities, NK cells participate in the development of a potent adaptive immune response. Furthermore, NK cells were found to have regulatory functions to limit and prevent autoimmunity via killing of autologous immune cells. These paradoxical functions of NK cells are reflected in CNS disorders. In this review, we discuss the phenotypes and functional features of peripheral and brain NK cells in brain tumors and infections, neurodegenerative diseases, acute vascular and traumatic damage, as well as mental disorders. We also discuss the implication of NK cells in neurotoxicity and neuroprotection following CNS pathology, as well as the crosstalk between NK cells and brain-resident immune cells.

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Immune profiling of Alzheimer patients

Cited by 128 publications

References 44 publications

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

Alzheimer’s disease and gut microbiota

NK Cells in Central Nervous System Disorders

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