2020
DOI: 10.1101/2020.03.12.20035048
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19

Abstract: Background: A recently emerging respiratory disease named coronavirus disease 2019 (COVID-19) has quickly spread across the world. This disease is initiated by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and uncontrolled cytokine storm, but it remains unknown as to whether a robust antibody response is related to clinical deterioration and poor outcome in laboratory-confirmed COVID-19 patients. Methods: Anti-SARS-CoV-2 IgG and IgM antibodies were determined by chemiluminescence analysis (CLIA)… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

19
212
1
6

Year Published

2020
2020
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 184 publications
(241 citation statements)
references
References 14 publications
19
212
1
6
Order By: Relevance
“…The results of our study indicated that convalescent patients had a higher antibody level than inpatients, which highlight the positive correlation between recovery and days since onset (Spearman correlation coefficient=0.5426, P<0.0001). Besides, we also found that antibody levels in asymptomatic or mild patients were slightly lower than moderate or severe patients, which was in line with other previous studies [16][17] . Zhang [17] came to a similar conclusion that severe cases were more frequently found in COVID-19 patients with high IgG levels, compared to those who with low IgG levels.…”
Section: Discussionsupporting
confidence: 93%
See 2 more Smart Citations
“…The results of our study indicated that convalescent patients had a higher antibody level than inpatients, which highlight the positive correlation between recovery and days since onset (Spearman correlation coefficient=0.5426, P<0.0001). Besides, we also found that antibody levels in asymptomatic or mild patients were slightly lower than moderate or severe patients, which was in line with other previous studies [16][17] . Zhang [17] came to a similar conclusion that severe cases were more frequently found in COVID-19 patients with high IgG levels, compared to those who with low IgG levels.…”
Section: Discussionsupporting
confidence: 93%
“…Besides, we also found that antibody levels in asymptomatic or mild patients were slightly lower than moderate or severe patients, which was in line with other previous studies [16][17] . Zhang [17] came to a similar conclusion that severe cases were more frequently found in COVID-19 patients with high IgG levels, compared to those who with low IgG levels. Previous data showed that severe SARS-CoV was also associated more robust serological responses including early seroconversion and higher IgG levels [18][19] .…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…All sera collected 29 or more days after onset of illness were antibody-positive in all four serological tests, findings similar to another recent report [14]. The OD levels in the IgG ELISA were statistically significantly higher in severe/critical cases, a finding also reported by others [14,15] but as the investigated number of patients remains small, these findings need to be confirmed in a larger patient cohort.…”
Section: Discussionsupporting
confidence: 89%
“…This compassionate-use program was initiated to understand the feasibility of suppressing CRP production with siltuximab and improving the outcomes in patients with COVID-19 requiring CPAP or NIV for pneumonia/ARDS treatment. Initial evidence from China where the first cases of COVID-19 emerged, indicate that excessive production inflammatory markers, such as IL-6 and CRP, correlate with severity of disease (Chen X et al 2020;Conti P et al 2020;Diao B et al 2020;Gong J et al 2020;Liu et al 2020;Yang et al 2020), and many more studies report a significant increase in IL-6 or CRP levels in patients with severe or critical COVID-19 compared with those patients with mild disease (Cai et al 2020;Chen J et al 2020;Feng C et al 2020;Huang Y et al 2020;Liu J et al 2020;Qin C et al 2020;Ruan Q et al 2020;Shi Y et al 2020;Wang Y et al 2020;Wang Z et al 2020;Wu C et al2020;Xu W et al 2020;Xu X et al 2020;Zeng Q et al 2020;Zhao Z et al 2020;Zhang B et al 2020;Zhou F et al 2020;Zhou Y et al 2020).…”
Section: Discussionmentioning
confidence: 99%