Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients

Manner, Ingjerd W.; Waldum-Grevbo, Bård; Witczak, Birgit Nomeland; Bækken, Morten; Øktedalen, Olav; Os, Ingrid; Schwartz, Thomas; Sjaastad, Ivar

doi:10.1080/08037051.2017.1346459

Cited by 4 publications

(4 citation statements)

References 61 publications

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“… 17 Clinical studies report an attenuation of diurnal blood pressure rhythms in HIV-infected patients that may be due to their compromised immune status. 60 , 61 Premature immune aging and non-AIDS-related diseases increase in HIV patients with age. 62 Importantly, rhythmic activities such as sleep/wake patterns change with increasing age, 63 consistent with reports of disturbed sleep in HIV infection 64 , 65 and delayed circadian rhythms in older Africans living with HIV.…”

Section: Discussionmentioning

confidence: 99%

Molecular components of the circadian clock regulate HIV-1 replication

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Molecular components of the circadian clock regulate HIV-1 replication

et al. 2023

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“…In contrast, Stern et al showed intact circadian transcriptional machinery in T cells from HIV infected subjects 20 . Clinical studies report an attenuation of diurnal blood pressure rhythms in HIV infected patients that may be due to their compromised immune status 60,61 . Pre-mature immune aging and non-AIDS related diseases increase in HIV patients with age 62 .…”

Section: Discussionmentioning

confidence: 99%

Circadian regulation of human immunodeficiency virus type 1 replication

Borrmann

Ulkar

Kliszczak

et al. 2022

Preprint

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Human immunodeficiency virus 1 (HIV-1) is a life-threatening pathogen that still lacks curative therapies or vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism’s response to its environment and invading pathogens. Recent reports of diurnal variation in peripheral viral load in HIV-1 infected subjects highlights the need for mechanistic studies. Here, we demonstrate rhythmic HIV-1 replication in circadian-synchronised model systems and show the circadian transcription factors, BMAL1 and REV-ERB, bind conserved motifs in the HIV-1 promoter. REV-ERB competes with ROR for binding to the same regulatory motif, and we uncover a role for ROR inhibitors to perturb rhythmic HIV-1 replication and host gene expression. We demonstrate that many HIV-1 host factors are circadian regulated and likely to define rhythmic viral replication. In summary, this study increases our understanding of the mechanisms underlying the circadian regulation of HIV that can inform HIV therapy and management.

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“…Nondipper pattern was found more frequently in HIV-infected than in non-HIV patients in previous case–control studies. 45,46 In general populations, non-dipper pattern has been associated with psychological and social factors, such as depression and social isolation, or sleeping disorders such as obstructive sleep apnea syndrome or insomnia. Interestingly, these factors are particularly common in HIV-infected population.…”

Section: Discussionmentioning

confidence: 99%

Ambulatory Blood Pressure Monitoring in HIV-Infected Patients: Usefulness for Cardiovascular Risk Assessment

Gómez-Berrocal

Santos-Gil

Abad-Pérez

et al. 2020

J Int Assoc Provid AIDS Care

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Background: There is a lack of consensus regarding the risk of hypertension in HIV-infected patients compared to the general population. Ambulatory blood pressure monitoring (ABPM) is the most accurate method for the hypertension diagnosis. Nevertheless, it is rarely used in HIV clinical care. Materials and Methods: All HIV-infected patients who underwent 24 hours ABPM were included. The agreement between office blood pressure (BP) readings and ABPM was analyzed. The rate of patients with masked hypertension (MH), isolated clinical hypertension, and nocturnal hypertension was obtained. Furthermore, it was analyzed if the differences between both methods may affect the cardiovascular risk (CVR) assessment. Results: A total of 116 patients were included. The κ coefficient between office BP and ABPM was 0.248. Over a quarter of the cohort was diagnosed with MH—25.8% (CI 95% 17.7%-34.0%), and 12% (CI 95%: 6.1%-16.1%) was diagnosed with ICH. Moreover, 19% of patients had hypertension exclusively during the night. The patients classified as low risk according to the CVR scores had a different diagnosis with ABPM than with office BP ( P < .001). Conclusions: The agreement between office BP and ABPM was low in HIV-infected patients. Ambulatory BP monitoring is useful in HIV-infected patients as a hypertension diagnosis method, especially among patients classified as low risk.

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Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients

Abstract: Compromised immune status may contribute to attenuated diurnal BP profile as well as impaired diastolic function in well-treated HIV infection.

Cited by 4 publications

References 61 publications

Molecular components of the circadian clock regulate HIV-1 replication

Molecular components of the circadian clock regulate HIV-1 replication

Circadian regulation of human immunodeficiency virus type 1 replication

Ambulatory Blood Pressure Monitoring in HIV-Infected Patients: Usefulness for Cardiovascular Risk Assessment

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