Molecular components of the circadian clock regulate HIV-1 replication

Borrmann, Helene; Ulkar, Görkem; Kliszczak, Anna E.; Ismed, Dini; Schilling, Mirjam; Magrì, Andrea; Harris, James Michael; Balfe, Peter; Vasuvedan, Sridhar; Borrow, Persephone; Zhuang, Xiaodong; McKeating, Jane A.

doi:10.1016/j.isci.2023.107007

Cited by 1 publication

(2 citation statements)

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“…The main replication site of human immunodeficiency virus (HIV) are T cells, and it was demonstrated that clock transcription factors regulate viral gene expression [ 74 ]. This results in rhythmic viral replication in vitro [ 75 ] and in patients [ 76 , 77 ]. Macrophages and neutrophils can be infected by the intracellular parasite Leishmania .…”

Section: Interplay Between Clocks and Pathogens In Different Host Nichesmentioning

confidence: 99%

“…Hepatic viruses can promote the formation of hepatocellular carcinoma, Liver: hepatitis B virus [44,45,51], hepatitis C virus [46,48,50]. Blood: dengue virus [46], HIV [74][75][76][77], Leishmania [78], Plasmodium [86][87][88][89][90], Trypanosoma [91,92]. Respiratory tract: Aspergillus fumigatus [109,110], influenza virus [31,[97][98][99][100], respiratory syncytial virus [104], SARS-CoV-2 [101][102][103], Sendai virus [98], Streptococcus pneumoniae [107,108].…”

Section: The Livermentioning

confidence: 99%

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Crosstalk between circadian clocks and pathogen niche

Borrmann,

Rijo-Ferreira

2024

PLoS Pathog

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Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation and response to daily environmental changes. These rhythms manifest across entire organisms, in various organs, and through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, and fungi, some of which have their own circadian rhythms while others are influenced by the rhythmic environment of hosts. Pathogens target specific tissues and organs within the host to optimize their replication. Diverse cellular compositions and the interplay among various cell types create unique microenvironments in different tissues, and distinctive organs have unique circadian biology. Hence, residing pathogens are exposed to cyclic conditions, which can profoundly impact host–pathogen interactions. This review explores the influence of circadian rhythms and mammalian tissue-specific interactions on the dynamics of pathogen–host relationships. Overall, this demonstrates the intricate interplay between the body’s internal timekeeping system and its susceptibility to pathogens, which has implications for the future of infectious disease research and treatment.

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