Immune-enhancing effects of polysaccharides MLN-1 from by-product of Mai-luo-ning
            <i>in vivo</i>
            and
            <i>in vitro</i>

Nie, Linfeng; Xiao, Qiuping; Liu, Shuangshuang; Li, Bo; Duan, Jin‐Ao; Fan, Yanhong; Li-wei, Guo; He, Chenghua; Zhu, Hua

doi:10.1080/09540105.2019.1582612

Cited by 6 publications

(4 citation statements)

References 35 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, diverse physiological activities of polysaccharide have been reported. Polysaccharides are usually extracted from plants, and many plant-derived polysaccharides have non-or less toxicity and few side effects (Nie et al, 2019). For these reasons, the ability of polysaccharide as functional food is being reevaluated.…”

Section: Chemical Characterization Of the Four Polysaccharidesmentioning

confidence: 99%

Polysaccharide isolated from Korean-style soy sauce activates macrophages via the MAPK and NK-κB pathways

et al. 2021

View full text Add to dashboard Cite

Soy sauce is a staple fermented food in Korea, however, there are relatively limited studies on soy sauce in Korea compared to that in Japan. In this study, the immuno-stimulating activities are compared in polysaccharides isolated from soy sauce in Korea and Japan. Crude polysaccharides was isolated, and which were named as Korean-style soy sauce (KSS-0) and Japanese-style soy sauce (JSS-0). Then, difference in cytokine production was compared in peritoneal macrophages, and KSS-0 showed higher cytokine production than JSS-0. The KSS-0 was purified into two polysaccharides, which were named as KSS-I and KSS-II. The polysaccharides consisted mainly galacturonic acid, xylose, and galactose. Out of the four polysaccharides isolated, KSS-II enhanced NO and cytokines production the most. Western blot analysis showed that KSS-II phosphorylated the MAPKs and nuclear factor NF-κB in RAW 264.7 cells in a dose-dependent manner. These results suggested that KSS-II activates macrophages via the MAPK and NF-κB pathways, and also induces an increase in the cytokine production. In conclusion, the polysaccharides isolated from Korean soy sauce have better immune-stimulating activities than those from Japan and may be used as potential functional foods.

show abstract

Section: Chemical Characterization Of the Four Polysaccharidesmentioning

confidence: 99%

Polysaccharide isolated from Korean-style soy sauce activates macrophages via the MAPK and NK-κB pathways

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It is involved in mediating cellular material transport, and as the sign of the gut mechanical barrier and epithelial integrity, it also plays a role in the process of cell proliferation, tumour cell metastasis and gene transcription (Liu et al, 2017;Stevenson et al, 1986). Due to the large molecular weight, FVP cannot be absorbed by mouse intestinal epithelium, but it can interact with mouse spleen cells to initiate the mucosal immune system and maintain the integrity of intestinal mucosal barrier (Nie et al, 2019). The immune regulation of FVP in our result was similar to those reported for other mushroom polysaccharides (Ike et al, 2012;Wang et al, 2014).…”

Section: Fvp Regulated the Relative Mrna Expressions In Mice Colon Tissuementioning

confidence: 99%

In vitro and in vivo functional characterization of an immune activation Flammulina velutipes polysaccharide based on gut microbiota regulation

Zhao

Fang

et al. 2020

Food and Agricultural Immunology

View full text Add to dashboard Cite

Flammulina velutipes contains bioactive polysaccharides that can activate the immune system. Here we report the functional characterization in an immunomodulatory F. velutipes polysaccharide (FVP) both in vitro and in vivo. In cell experiment, FVP was discovered to be an activator to induce the M1polarization of the RAW 264.7 cells. In animal experiment, FVP was found to raise the gene expression of IL-1β, iNOS and ZO-1 in mice colon tissue. Moreover, it seemed to achieve the immune regulative function by raising the relative abundance of Allobaculum, Lactobacillus, Alloprevotella, Akkermansia and Bifidobacterium. Gut microbiota also caused the body's functional changes, enriched the harmful chemicals' degradation ability and weakened the metabolism of carbohydrates. These findings suggest that FVP is an immunomodulatory polysaccharide that can boost cellular immune responses and a potential prebiotic agent in regulating gut microbiota.

show abstract

“…Emphasizing recent works relating to lignin, wherein nanocomposite films based on cellulose, lignin, and polylactic acid have been reported to have antioxidant and antimicrobial properties, arising out of the phenolic groups in lignin [17]. In such composite systems, through detailed investigations, the advantages of nanocomposites have been established.…”

Section: Introductionmentioning

confidence: 99%

Potent antifungal agents and use of nanocarriers to improve delivery to the infected site: A systematic review

2021

View full text Add to dashboard Cite

There are four major classes of antifungals with the predominant mechanism of action being targeting of cell wall or cell membrane. As in other drugs, low solubility of these compounds has led to low bioavailability in target tissues. Enhanced drug dosages have effects such as toxicity, drug–drug interactions, and increased drug resistance by fungi. This article reviews the current state‐of‐the‐art of antifungals, structure, mechanism of action, other usages, and toxic side effects. The emergence of nanoformulations to transport and uniformly release cargo at the target site is a boon in antifungal treatment. The article details research that lead to the development of nanoformulations of antifungals and potential advantages and avoidance of the lacunae characterizing conventional drugs. A range of nanoformulations based on liposomes, polymers are in various stages of research and their potential advantages have been brought out. It could be observed that under similar dosages, test models, and duration, nanoformulations provided enhanced activity, reduced toxicity, higher uptake and higher immunostimulatory effects. In most instances, the mechanism of antifungal activity of nanoformulations was similar to that of regular antifungal. There are possibilities of coupling multiple antifungals on the same nano‐platform. Increased activity coupled with multiple mechanisms of action presents for nanoformulations a tremendous opportunity to overcome antifungal resistance. In the years to come, robust methods for the preparation of nanoformulations taking into account the repeatability and reproducibility in action, furthering the studies on nanoformulation toxicity and studies of human models are required before extensive use of nanoformulations as a prescribed drug.

show abstract

Immune-enhancing effects of polysaccharides MLN-1 from by-product of Mai-luo-ning in vivo and in vitro

Cited by 6 publications

References 35 publications

Polysaccharide isolated from Korean-style soy sauce activates macrophages via the MAPK and NK-κB pathways

Polysaccharide isolated from Korean-style soy sauce activates macrophages via the MAPK and NK-κB pathways

In vitro and in vivo functional characterization of an immune activation Flammulina velutipes polysaccharide based on gut microbiota regulation

Potent antifungal agents and use of nanocarriers to improve delivery to the infected site: A systematic review

Contact Info

Product

Resources

About