Immune Disorders of the Gastrointestinal Tract and Liver

Evaluation of B and T lymphocytes and plasma cells in colonic mucosa from healthy dogs and from dogs with inflammatory bowel disease

“…They are probably derived from the lamina propria. In human beings they are considered to be a morphologically, phenotypically and functionally heterogenous lymphoid cell population although in general it is considered that the majority are T lymphocytes [very few B cells are found in the intraepithelial compartment (Van der Heijden and Stok 1987)] and most are of the suppressorlcytotoxic phenotype (Bienenstock 1984, Harty and Leibach 1985, Brandtzaeg et al 1989, Carman et al 1986. It has been suggested in the dog that T cells migrate from the lamina propria towards the lumen in response to antigenic stimulation (Jergens et al 1996) and at least in man may return to the lamina propria and circulation after antigen priming to act in a sentinel role (Guilford et al 1996, Berk 1985.…”

Vitiligo, Rheumatoid Arthritis and Pernicious Anemia

“…Abnormalities in T cell function and in cellular immunity in vitro have been demonstrated in 85% of patients with PA (28,29). However, the function of deranged CMI as well as NK cells in the pathogenesis of PA has received relatively scant attention (30) and has not been fully defined (31).…”

“…We describe the first, and unusual, case of a woman presenting with the specific constellation of vitiligo, RA, and PA. The numerous reports examining the correlation between phenotypic and functional defects of lymphocytes and the pathogenesis of vitiligo, RA, and PA (9,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31), prompted us to investigate the cell-mediated immunity (eMI) profile of this individual. Peripheral blood mononuclear (PBMC) derived from the patient were studied in vitro for phenotypes, natural killers (NK) function, and response to mitogens.…”