Immune Complexes in Ovarian Cancer

Poulton, T. A.; Crowther, M. E.; Hay, Frank C.; Nineham, L J

doi:10.1016/s0140-6736(78)91383-1

Cited by 47 publications

(10 citation statements)

References 12 publications

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“…(Lynch et al, 1981). The inordinately high frequency of individuals with low serum IgA levels (Schuelke et al, 1982) in this kindred is consistent with the numerous observations of altered immune functions associated with ovarian cancer in the general population (Badger et al, 1981;Daunter et al, 1979;Gerber et al, 1977;Hess et al, 1979;Hughes 1971;Humphrey et al, 1977;Mandell et al, 1979;Mantovani et al, 1980a, b;Mikulski et al, 1977;Pattillo et al, 1979a, b;Poulton et al, 1978;Ueda et al, 1978Ueda et al, , 1979. We here report the results of tests relative to cellular immune functions in this kindred.…”

supporting

confidence: 84%

Cellular immune function study in an ovarian cancer-prone kindred

Schuelke¹,

Lynch²,

Lynch³

et al. 1982

Br J Cancer

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supporting

confidence: 84%

Cellular immune function study in an ovarian cancer-prone kindred

Schuelke¹,

Lynch²,

Lynch³

et al. 1982

Br J Cancer

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“…However, ascites fluids are known to contain immunosuppressive factors (Hess et al, 1979) as well as immune complexes (Poulton et al, 1978). Several attempts were made to influence activity in each assay by incubating normal blood mononuclear cells overnight with 18 different ascitic fluids, associated with either the most depressed or most active of values for ascitic NK activities.…”

Section: Association Of Cell Markers With Effector-cell Activitymentioning

confidence: 99%

Mononuclear-cell infiltration in ovarian cancer. II. Immune function of tumour and ascites-derived inflammatory cells

Haskill¹,

Koren²,

Becker³

et al. 1982

Br J Cancer

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Summary.-Mononuclear cell fractions were isolated from blood, ascites and solid tumours of patients undergoing surgery for Stages III and IV PHA responses of patient blood and ascites fractions were about half that of normal blood. Tumour-infiltrating lymphocytes (TIL) were less than 10% as responsive as normal blood. The depressed PHA responses of the TIL were not due to the presence of a suppressor cell population. NK activity of patient blood was less than that of normal blood, but not as much as the ascites or TIL cells. The activity of the ascites-derived lymphocytes was enhanced by treatment with interferon. ADCC activity against both CRBC and SB cells was normal or higher than controls in patient blood, and depressed in the ascites-derived fractions. TIL responded to <10% of the patient blood values.The results indicate a lack of response by ascitic and TIL cells in assays dependent on FcR -bearing effector cells and a greater loss of PHA-reactive cells from the tumour than from blood and ascites. These data could result from intratumour inactivation, or a failure of the particular subset to localize either In the ascites or the tumour site.

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“…Analysis of the value of CIC assays in the more common cancers cannot, therefore, be readily assessed by such stringent criteria. Given the small amount of data published in conditions in which relapses during chemotherapy are common (such as carcinoma of the ovary), it may be difficult to be certain whether rises in CIC concentrations which appear to predict relapse (Poulton et al, 1978) are caused by recurrent tumour or by the chemotherapy itself.…”

Section: Discussionmentioning

confidence: 99%