Circulating immune complexes as markers of response to chemotherapy in malignant teratomas and gestational trophoblastic tumours

Begent, R. H. J.; Chester, KA; Walker, L. C.; Tucker, D. F.

doi:10.1038/bjc.1982.36

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Using strict definitions of CIC positivity in our study (i.e., mean CIC plus threefold standard deviations of normal controls) we were not able to demonstrate such correlations even in patients presenting the highest CIC titers. A poor correlation between CIC titers, tumor mass and the tumor markers, beta-HCG and Alpha-1-fetoprotein has also been found in patients with teratocarcinoma and chorion epithelioma (Begent et al, 1982). Other authors, however, have claimed that CIC-positive patients have a worse prognosis than CIC-negative ones (Carpentier et al, 1980(Carpentier et al, , 1982.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of circulating immune complexes in patients with metastatic breast cancer

Krieger

Kehl

Wander

et al. 1983

Intl Journal of Cancer

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Serum circulating immune complexes (CIC) were repeatedly measured by means of the CIq binding assay (Cba) and the Raji cell assay (Rca) in 158 patients with metastatic breast cancer (mbc). Frequency of occurrence and levels of CIC were only slightly increased in mbc when compared to age-matched healthy women. They were identical to those of patients with localized breast cancer prior to mastectomy and to those of post mastectomy patients without evidence of recurrent disease. In mbc the results of the Cba and the Rca showed a poor correlation, whereas in a control group of patients with rheumatoid arthritis both tests showed significantly elevated levels of CIC. Patients with mbc were followed up clinically and biochemically by serially measuring CIC for an average of 10 months. Patients with positive CIC did not prove to be an unfavorable group regarding progression of disease and response to chemotherapy. When CEA and CIC levels were compared, CIC, unlike CEA, was a poor tumor marker. In conclusion, CIC as measured by CIq binding assay and Raji cell assay are not clinically significant tumor markers or prognostic indicators in patients with metastatic breast cancer.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of circulating immune complexes in patients with metastatic breast cancer

Krieger

Kehl

Wander

et al. 1983

Intl Journal of Cancer

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“…The percentages of CD16 þ were evaluated microscopically, using slides stained by Giemsa stain. Serum immune complex levels were measured by using the polyethylene glycol assay described by Begent et al (1982). Phagocytes activity was assessed by using latex article (diameter 1.0 to 1.3) and phagocytes index were calculated (Pruzanski et al, 1983).…”

Section: Tests Of Immune System Functionmentioning

confidence: 99%

Low internal radiation alters innate immune status in children with clinical symptom of irritable bowel syndrome

2010

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Adverse health effect of low radiation is clear. The aim of this study was to determine effect of internal low radiation on innate immune status in Ukrainian children with spastic colitis as a result of Chernobyl disaster. The test population consisted of 95 participants: 75 rural participants with clinical symptom of irritable bowel syndrome, aged 4 to 18, who lived in a contaminated area exposed to radio nucleotide due to the disaster in reactor in Chernobyl nuclear power plant (categorized in three groups) and 20 healthy urban participants from Kiev, aged 5 to 15, as the control group. Internal radiation activity has been measured by gamma-ray spectrometry. Peripheral blood leukocytes were analyzed for CD16(+) subset, serum concentration of circulation immune complex was measured by the polyethylene glycol method. Phagocytic activity function was assessed by using latex article and phagocytic index were calculated. p < 0.05 was considered significant. Percent of CD16(+) cell in groups II and III increased significantly in comparison to control group (p < 0.05). Concentration of circulating immune complexes increased significantly in all study groups compared to control group (p < 0.001). Phagocytes activity and phagocyte index decreased significantly in all study groups in comparison to control group (p < 0.001). The innate immune status of study groups has changed. Our data have demonstrated that this change may be related to radioactivity from technogenic pollution due to the disaster in reactor in Chernobyl nuclear power plant.

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Circulating immune complexes in chronic myeloid leukemia patients at various stages of the disease

Saranath¹,

Advani

Gangal³

1983

Leukemia Research

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Circulating immune complexes as markers of response to chemotherapy in malignant teratomas and gestational trophoblastic tumours

Cited by 3 publications

References 15 publications

Clinical significance of circulating immune complexes in patients with metastatic breast cancer

Clinical significance of circulating immune complexes in patients with metastatic breast cancer

Low internal radiation alters innate immune status in children with clinical symptom of irritable bowel syndrome

Circulating immune complexes in chronic myeloid leukemia patients at various stages of the disease

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