Immune complex glomerulonephritis in sicca syndrome

Sjogren's Syndrome Complicated with IgA Nephropathy and Leukocytoclastic Vasculitis

“…Glomerular involvement and primary Sjögren's syndrome has been described previously only in isolated case reports, where membranous nephropathy and membranoproliferative glomerulonephritis have been presented. [5][6][7][8][9][10][11] Dabadghao et al [12] reported proliferative glomerulonephritis leading to end stage renal disease in a patient with primary SS. Mon et al [13] reported a case of minimal change disease and glomerular IgA deposition associated with Sjögren's syndrome.…”

A superfemale with primary Sjögren's syndrome which involved systemic organs

“…In contrast to interstitial nephritis, glomerulonephritis is rather rare in patients with primary SS and only sporadic cases have been reported [4,7]. In this case, severe lymphocytic infiltrate was observed in not only the renal interstitium but also glomerulus, resulting in interstitial nephritis and glomerulonephritis.…”

“…In this case, however, arterioles and glomerular capillaries were not affected, so the glomerulonephritis in this case was considered to be caused by primary SS. Moutsopoulos et al reported rapid improvement in renal function following moderate doses of corticosteroids [4] and, as the proteinuria observed in that case was significantly improved after two years of treatment, we must follow up this case several more years.…”

“…Corticosteroid therapy has been suggested to promote resolution of the lymphocyte infiltration in some patients with Sjögren's syndrome [3][4][5]. We initiated corticosteroid therapy, a methyl-predonisolone pulse therapy, 500 mg day Ϫ1 for three days, followed by 20 mg day Ϫ1 , p.o.…”

Sjögren's Syndrome

“…The typical renal histopathological alteration is an interstitial lymphocytic infiltration with tubular atrophy and sometimes fibrosis. Immunecomplex glomerulonephritis has been described by light and electron microscopy of renal biopsies (47). Renal tubular acidosis, so-called nephrogenic diabetes insipidus, and rarely, aminoaciduria (Fanconi's syndrome) are also seen.…”