Immune-Complex Deposition in the Eye in Systemic Lupus Erythematosus

Aronson, Andrew J.

doi:10.1001/archinte.1979.03630480084026

Cited by 105 publications

(37 citation statements)

References 6 publications

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“…This is in contrast to classic forms of systemic vasculitis such as SLE where a type III hypersensitivity reaction deposits immune complexes within the vessel wall followed by fibrinoid necrosis. [7][8][9] When antiphospholipid antibodies are present in lupus, more severe vasoocclusive disease can be seen with occlusion of arteries. 10,11 In antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis both orbital inflammation and scleritis can occur.…”

Section: Pathogenesismentioning

confidence: 99%

Imaging Retinal Vascular Changes in Uveitis

Bhaleeya¹,

Davis²

2012

International Ophthalmology Clinics

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Section: Pathogenesismentioning

confidence: 99%

Imaging Retinal Vascular Changes in Uveitis

Bhaleeya¹,

Davis²

2012

International Ophthalmology Clinics

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“…Immune complex depositions (Fig. 2) have been localized in the retinal and choroidal vessel wall/lumen (Aronson et al, 1979;Karpik et al, 1985;Nag and Wadhwa, 2005), and are considered to be responsible for vasculitis. In another situation, immune complexes/autoantibodies may interact with platelet and/or endothelial cell surfaces, deposit in the vessel lumen and cause vascular occlusion in absence of inflammation (occlusive vasculitis).…”

Section: Vasculitis Associated With Slementioning

confidence: 99%

Vascular Changes of the Retina and Choroid in Systemic Lupus Erythematosus: Pathology and Pathogenesis

Nag¹,

Wadhwa

2006

CNR

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects multiple organ systems. When eyes are involved, the principle manifestations are hemorrhage, retinal cotton wool spots, microangiopathy and vaso-occlusion. Research in the past two decades has significantly contributed to our understanding about this disease in general and its therapeutic management, although knowledge about the mechanism of ocular involvement and pathogenesis in SLE is limited. This is an important issue, because the ocular symptoms in this disease could be potentially sight threatening in acute cases. Here, we present an overview of the clinical and histopathologic features of retinal and choroidal vascular changes, as seen in patients with SLE. We discuss the role of immune complex deposition in vascular pathogenesis in the eye. Reports indicated an involvement of antiphospholipid antibodies (APAs) in the retinal and choroidal vasculopathy in SLE, although their precise role in this process is uncertain. It is important to look for mechanisms of immune complex-mediated vasculopathy and role of inflammatory mediators in this process in SLE. For this, established animal models can be utilized in research to learn about the precise role of various autoantibodies and complements involved in disease pathogenesis. A clear knowledge about the immunopathogenesis is warranted, and the rationale for the future therapy should be based on reducing vascular inflammation as well as ameliorating autoimmunity in this disease.

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“…18 Histopathological studies in lupus choroidopathy have demonstrated an infiltration of mononuclear cells and immunoglobulin deposition in the vascular layer of choroid capillaries. 20, 21 We administered prednisolone and cyclophosphamide in this case because the combination therapy has been shown to be effective in patients with lupus choroidopathy and systemic vascular disease. 22,23 This therapy successfully resulted in recovered vision, and also stopped protein loss from the intestines, indicating that the immune mechanism might be responsible for the patient's choroidopathy and protein-losing gastroenteropathy, as well as her mononeuritis multiplex.…”

Section: Discussionmentioning

confidence: 99%

Mononeuritis multiplex, protein-losing gastroenteropathy, and choroidopathy seen together in a case of systemic lupus erythematosus

Hirabayashi

Saito

Takeshita

et al. 2003

Modern Rheumatology

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A 43-year-old woman with systemic lupus erythematosus (SLE) had an episode of mononeuritis multiplex prior to developing protein-losing gastroenteropathy. Four years later, she had another episode of mononeuritis multiplex, followed by choroidopathy. These manifestations are uncommon in SLE, but may be attributed to vasculitis. The laboratory findings indicated that the elevation of D-dimer and thrombin-antithrombin complex levels seen in this case might be useful in evaluating vascular lesions in SLE.

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Immune-Complex Deposition in the Eye in Systemic Lupus Erythematosus

Cited by 105 publications

References 6 publications

Imaging Retinal Vascular Changes in Uveitis

Imaging Retinal Vascular Changes in Uveitis

Vascular Changes of the Retina and Choroid in Systemic Lupus Erythematosus: Pathology and Pathogenesis

Mononeuritis multiplex, protein-losing gastroenteropathy, and choroidopathy seen together in a case of systemic lupus erythematosus

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