Mononeuritis multiplex, protein-losing gastroenteropathy, and choroidopathy seen together in a case of systemic lupus erythematosus

Abstract

A 43-year-old woman with systemic lupus erythematosus (SLE) had an episode of mononeuritis multiplex prior to developing protein-losing gastroenteropathy. Four years later, she had another episode of mononeuritis multiplex, followed by choroidopathy. These manifestations are uncommon in SLE, but may be attributed to vasculitis. The laboratory findings indicated that the elevation of D-dimer and thrombin-antithrombin complex levels seen in this case might be useful in evaluating vascular lesions in SLE.

Systemic lupus erythematosus complicated with protein‐losing enteropathy: A case report and review of the published works

“…In Table 1, we summarize the 43 reported cases of PLE associated with connective tissue disease during the past 22 years, including our present case 2–4,10–42 . Affected patients consisted of seven males and 36 females, and the average age was 34.6 years (ranging 11 months to 79 years).…”

“…The associated collagen diseases included 28 cases of SLE, seven cases of Sjögren’s syndrome and two cases of mixed connective tissue disease (MCTD). Two patients with concurrent SLE and Sjögren’s syndrome were included in the count for both SLE and Sjögren’s syndrome, 3,28 and one case diagnosed as either SLE or MCTD was counted as SLE 17 . In addition, there were eight cases of PLE with a high antinuclear antibody (ANA) titer and hypocomplementemia that did not satisfy the diagnostic criteria for a specific connective tissue disease; these cases were counted as unclassified connective tissue disease (UCTD).…”