Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis

Weinstock‐Guttman, Bianca; Zivadinov, Robert; Tamaño‐Blanco, Miriam; Abdelrahman, Nadir; Badgett, Darlene; Durfee, Jacqueline; Hussein, Sara; Feichter, Joan; Patrick, Kara; Benedict, Ralph H. B.; Ramanathan, Murali

doi:10.1016/j.jneuroim.2007.06.003

Cited by 57 publications

(65 citation statements)

References 25 publications

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“…The MT post-processing was completely automated [25,26]. The MTR of T2 and T1-LVs, normal appearing (NA) brain tissue (NABT) MTR, NAWM MTR and NAGM MTR were obtained.…”

Section: Brain Measuresmentioning

confidence: 99%

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Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

Frohman

Dwyer

Frohman

et al. 2009

Journal of the Neurological Sciences

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109

105

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“…The MT post-processing was completely automated [25,26]. The MTR of T2 and T1-LVs, normal appearing (NA) brain tissue (NABT) MTR, NAWM MTR and NAGM MTR were obtained.…”

Section: Brain Measuresmentioning

confidence: 99%

“…The MTR of T2 and T1-LVs, normal appearing (NA) brain tissue (NABT) MTR, NAWM MTR and NAGM MTR were obtained. Given the superior reliability of mean MTR, and in order to minimize the number of multiple statistical tests, the analyses emphasized the mean MTR measure [25,26].…”

Section: Brain Measuresmentioning

confidence: 99%

Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

Frohman

Dwyer

Frohman

et al. 2009

Journal of the Neurological Sciences

Self Cite

109

105

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“…MT images were co-registered to a native acquisition space PD image [34,37]. The FLAIR lesion masks were used to nullify overt lesions, and the remaining PD was algebraically combined with the coregistered PD ?…”

Section: Mri Analysismentioning

confidence: 99%

MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis

et al. 2009

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MRI findings of primary anti-phospholipid antibody syndrome (PAPLS) are difficult to distinguish from those of multiple sclerosis (MS). Only a few previous studies have compared conventional and non-conventional MRI findings in MS and PAPLS patients. In addition, MRI differences between anti-phospholipid antibody (APLA) positive (+) and APLA negative (-) MS patients have not been reported. Therefore, the aim of this study was to investigate the differences in MRI measures among patients with PAPLS, MS and normal control (NC) subjects. We also explored non-conventional MRI measures in APLA+ and APLA- MS patients. Forty-nine (49) consecutive MS patients among whom 39 had relapsing-remitting (RR) and 10 secondary-progressive (SP) disease course, 30 patients with PAPLS and 49 NC were enrolled. Twenty-eight (28) MS patients were APLA+. MRI measures of T1- and T2-lesion volumes (LV) and brain atrophy, including fractions of whole brain (BPF), gray matter (GMF) and white matter (WMF), were evaluated. The magnetization transfer ratio (MTR) of T2- and T1-LVs and different normal-appearing brain tissue (NABT) compartments as well as diffusion-weighted imaging of whole brain mean parenchyma diffusivity (MPD) were obtained. MS patients differed significantly from NC in all MRI measures. PAPLS patients differed from NC in their T2-LV, in MTR measures and in MPD. When MS patients were compared to PAPLS patients, they showed significantly higher T2- and T1-LVs and T2-LV MTR, lower BPF and GMF and higher MPD. APLA+ RR and SPMS (all APLA+) patients showed significantly higher T2-LV, lower GMF, lower normal-appearing gray matter MTR and higher MPD when compared to APLA- patients. The results indicate that brain abnormalities can be detected in PAPLS patients with non-conventional MRI. MRI reveals more profound injury in patients with MS versus PAPLS. APLA mediates heterogeneous cerebral pathology that remains to be further investigated.

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“…Brain-derived neurotrophic factor (BDNF) can be secreted by both neurons and immune cells in MS brains. A complicated interaction between BDNF levels and MS pathology is suggested by correlations of immune cell BDNF secretion, which can be activity dependent, and imaging parameters of white and gray matter volume [67,68]. Finally, immunomodulatory treatments themselves can regulate neurotrophin expression and/or directly interact with neurotrophic signaling pathways [69], suggesting that immune cellmediated delivery of neurotrophic factors should be taken into consideration in designing repair strategies in MS.…”

Section: How To Integrate Strategies To Prevent Axon Damage or Promotmentioning

confidence: 99%

Myelin repair strategies: a cellular view

Gallo

Armstrong

2008

Current Opinion in Neurology

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Purpose of review-The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the CNS of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyelination and remyelination processes, it should be expected that effective therapeutic approaches will require a combination of strategies for immunomodulation, neuroprotection, and myelin replacement. This brief review highlights recent cellular and molecular findings and indicates that future therapeutic strategies to enhance remyelination may also require combinatorial treatment to accomplish.Recent findings-The relapsing-remitting course of some forms of MS has typically fueled hope for effective repair of MS lesions if demyelinating activity could be attenuated. Recent findings support the potential of endogenous neural stem cells and progenitor cells to generate remyelinating oligodendrocytes. Importantly, interactions with viable axons and supportive astrocytic responses are required for endogenous immature cells to fulfill their potential remyelinating capacity. Summary-The research described here will help in identifying the major obstacles to effective remyelination and potential therapeutic targets to guide development of comprehensive approaches for testing in animal models and eventual treatment of patients with MS.

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Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis

Cited by 57 publications

References 25 publications

Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis

Myelin repair strategies: a cellular view

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