Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

Frohman, Elliot M.; Dwyer, Michael G.; Frohman, Teresa C.; Cox, Jennifer L.; Salter, Amber; Greenberg, Benjamin; Hussein, Sara; Conger, Amy; Calabresi, Peter A.; Balcer, Laura J.; Zivadinov, Robert

doi:10.1016/j.jns.2009.04.010

Cited by 109 publications

(123 citation statements)

References 31 publications

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“…Based on these data, the RNFL thickness (RNFLT) and TMV have been proposed as potential surrogate outcome measures of neuro-axonal degeneration in MS [14]. Recent studies suggest that OCT measures of retinal degeneration correlate with MRI measures of brain tissue loss [17][18][19][20][21]. As a limitation of all these studies, time domain OCT (TD-OCT) has been used as opposed to the more advanced and more accurate spectral domain OCT technique (SD-OCT), with faster data acquisition, greater reliability and higher resolution [17,22].…”

Section: Introductionmentioning

confidence: 99%

Loss of retinal nerve fibre layer axons indicates white but not grey matter damage in early multiple sclerosis

Young

Brandt

Petzold

et al. 2013

Euro J of Neurology

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BACKGROUND AND PURPOSE: Optical coherence tomography (OCT) has shown thinning of the retinal nerve fibre layer (RNFL) and total macular volume (TMV) in multiple sclerosis (MS) patients. Measures of retinal atrophy are associated with the brain parenchymal fraction (BPF) assessed by magnetic resonance imaging (MRI). However, in MS, data on the relation of OCT measures and grey and white matter volumes are contradictory. We performed a prospective cross-sectional study with a statistically pre-defined endpoint to test our hypothesis that OCT measures of neuro-axonal degeneration are related to global and partial brain atrophy in early forms of MS. METHODS AND RESULTS: Fortyfour patients with clinically isolated syndrome (n = 10) or relapsing-remitting MS (n = 34; mean disease duration = 3.2 years, median EDSS = 1.5) were enrolled in the study. Peripapillary-and volumetric OCT scans of the macula were performed using latest spectral-domain OCT technology. BPF as well as white and grey matter fractions (WMF/GMF) were assessed by 1.5 Tesla MRI scans. Generalized estimating equation models adjusted for age and linear regression statistics were used to assess the association between OCT and MRI measures. RNFL thickness, TMV and age were significantly associated with BPF. RNFL thickness and TMV independently predicted WMF (P = 0.003 and P = 0.032) but not GMF (P = 0.717 and P = 0.357) when corrected for age. In contrast, age was strongly associated with GMF (P < 0.001) but not WMF. CONCLUSION: Our study suggests that, in early MS, OCT measures of retinal atrophy are related to volumetric changes in the white but not grey matter compartment as assessed by MRI. It further substantiates the association of retinal thinning and brain tissue loss in MS. We performed a cross-sectional study with a statistically pre-defined endpoint to test our hypothesis that OCT measures of neuro-axonal degeneration are related to global and partial brain atrophy in early forms of MS.44 patients with clinically isolated syndrome (CIS, n=10) or relapsing remitting MS (RRMS, n=34) (mean disease duration=3.2 years, median EDSS=1.5) were enrolled in the study. Peripapillary-and volumetric OCT scans of the macula were performed using latest spectral-domain OCT technology. BPF as well as white and grey matter fractions (WMF/GMF) were assessed by 1.5 T MRI scans. Generalized estimating equation models (GEE) adjusted for age and linear regression statistics were used to assess the association between OCT and MRI measures.RNFL thickness, TMV and age were significantly associated with BPF. RNFL thickness, and TMV independently predicted WMF (p=0.003 and p=0.032) but not GMF (p=0.717 and p=0.357) when corrected for age. In contrast, age was strongly associated with GMF (p<0.001) but not WMF.

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Section: Introductionmentioning

confidence: 99%

Loss of retinal nerve fibre layer axons indicates white but not grey matter damage in early multiple sclerosis

Young

Brandt

Petzold

et al. 2013

Euro J of Neurology

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“…These OCTs offer faster scan speed and higher image resolution for RNFL imaging than conventional time-domain OCT. 2 Several studies have focused on the measurements and reproducibility of RNFL thickness using Stratus-OCT after optic neuritis (ON) and multiple sclerosis (MS). [3][4][5][6][7][8][9][10][11][12][13] In fact, lower RNFL values correlate with impaired visual function. OCT is a promising tool for evaluating atrophy in patients with ON and MS, and it could evolve into an important primary or secondary outcome measure for MS clinical trials and patient care.…”

Section: Introductionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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Purpose To study the relationship between retinal nerve fiber layer (RNFL) thickness measurements from time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT) in subjects with optic neuritis. Methods A total of 18 patients who had suffered monocular acute optic neuritis were imaged by a single trained operator using the Stratus-OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) on the same day. The relationship between RNFL thickness measurements of the two OCTs (overall and by quadrants) were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman plots. Comparisons between eyes having optic neuritis (ON-group) and fellow eyes (fellow-group) were assessed by a generalized estimating equation (GEE) regression model.

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“…Petzold A et al [14] meta-analyzed 12 studies regarding RNFL in eyes with multiple sclerosis optic neuritis (MS ON) [12,[15][16][17][18][19][20][21][22][23][24] . They observed significant average RNFL loss -20.38 µm in MSON eyes (95% CI, -22.86 to -17.91).…”

Section: Discussionmentioning

confidence: 99%

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

Kitthaweesin

Sutra

2013

JBGC

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Background: The majority of optic neuritis patients often notice improvement and gain stability of their visual functions, however, evidences of ongoing retinal nerve fiber layer (RNFL) thinning have been reported. Purposes:To investigate the correlation between RNFL thickness measured with Optical coherence tomography (OCT) and visual function tests and to determine the utility of OCT in visual prognostic assessment of optic neuritis. Method:A prospective study was performed in 12 patients with acute isolated optic neuritis. Best corrected visual acuity (BCVA), Swedish interactive threshold algorithms (SITA) 30-2 strategy on Humphrey field analyzer, and fast RNFL thickness analysis were performed on both affected and fellow eyes at baseline, 1.5, three and six months.Results: Mean BCVA and average mean deviation (MD) of the affected eye were significantly different from the fellow eyes at baseline. Affected eyes had significant thinner of RNFL at baseline, 1.5, three, and six months. Significant correlations between (i) mean RNFL thickness and BCVA at 1.5 (r = 0.707, p = .010), (ii) mean RNFL thickness and MD at 1.5 months (r = 0.674, p = .016) and six months(r = 0.710, p = .032), (iii) mean RNFL thickness at 1.5 months and MD at six months (r = 0.782, p = .013). Conclusion:A correlation between RNFL thickness and visual function tests indicates that OCT might have roles in detection and prediction of RNFL damage in Optic neuritis (ON) patients despite no evidence of MS.

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Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

Cited by 109 publications

References 31 publications

Loss of retinal nerve fibre layer axons indicates white but not grey matter damage in early multiple sclerosis

Loss of retinal nerve fibre layer axons indicates white but not grey matter damage in early multiple sclerosis

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

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