Immune activation markers to predict AIDS and survival in HIV-1 seropositives

Fuchs, Dietmar; Jäger, H.; Popescu, M.; Reibnegger, Gilbert; Werner, Ernst R.; Dierich, Manfred P.; Kaboth, W; Tilz, Gernot P.; Wächter, Helmut

doi:10.1016/0165-2478(90)90178-s

Cited by 44 publications

(23 citation statements)

References 19 publications

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“…Notably, in earlier investigations on patients with HIV infection, the association between neopterin and soluble interleukin-2 receptor concentrations was also found to be rather weak (16,22). The size of the study is, however, too small for a final conclusion.…”

Section: Discussionmentioning

confidence: 53%

Stimulated Cellular Immune System in Patients with Congestive Heart Failure

Fuchs

Samsonov²,

Gp³

et al. 1993

Clinical Chemistry and Laboratory Medicine

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Summary:In this cross-sectional study, we analysed serum concentrations of soluble markers of cellular immune activation, namely, interferon-γ, neopterin (a product of activated macrophages), soluble interleukin-2 receptor, and soluble CDS, in 25 patients with congestive heart failure. Ten (40%) patients showed increased concentrations (i.e. above the reference ranges of healthy controls) of neopterin, 14 (56%) showed increased soluble interleukin-2 receptor, and 6 (24%) showed increased soluble CDS. Endogenous interferon-γ was detectable in 10 patients (40%). In addition, we found significant correlations between neopterin and interferon-γ (rs = 0.417, p < 0.05), and between neopterin and soluble CDS concentrations (rs = 0.430, p < 0.05). All patients with increased soluble CDS also had increased soluble interleukin-2 receptor. However, no significant correlations of soluble interleukin-2 receptor with soluble CDS or any of the other quantities were observed.

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Section: Discussionmentioning

confidence: 53%

Stimulated Cellular Immune System in Patients with Congestive Heart Failure

Fuchs

Samsonov²,

Gp³

et al. 1993

Clinical Chemistry and Laboratory Medicine

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“…Increased serum concentrations of sCD8 have been reported in HIVϩ patients in numerous studies (1,12,25,40,41,45), and found to be correlated with other phenotypic and serological markers of lymphocyte activation and poor prognosis (3,27,40,49,52). Prince et al (48,49) found, in contrast to Agostini et al (1), that sCD8 levels were correlated with CD4 cell counts and suggest that activation of CD8 cells and the destruction of CD4 cells are related.…”

Section: Discussionmentioning

confidence: 83%

Indicators of T-cell activation: Correlation between quantitative CD38 expression and soluble CD8 levels in asymptomatic HIV+ individuals and healthy controls

et al. 1998

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“…Among infectious diseases neopterin has been extensively studied in patients with human immunodeficiency virus 1 (HIV-1) infection (46)(47)(48)(49). Neopterin concentrations are increased early in the infection, correlate negatively with CD4 T cell counts and predict prognosis.…”

Section: Neopterin As Biomarker Of Immune Activationmentioning

confidence: 99%