Abstract:The Stimulator of Interferon Genes (STING) pathway represents a major innate immune sensing mechanism for tumor-derived DNA. Modified cyclic dinucleotides (CDNs) that mimic the endogenous STING ligand cGAMP are currently being explored in patients with solid tumors that are amenable to intratumoral delivery. Inadequate bioavailability and insufficient lipophilicity are limiting factors for clinical CDN development, in particular when consideration is given to systemic administration approaches. We have shown t… Show more
“…118,119 In addition, they also developed STING-activated spherical nucleic acids, which can effectively activate the cGAS-STING pathway to generate innate immune responses. 120 The development of SNAs that can activate the innate or adaptive immune system and elicit a potent anti-cancer immune response has demonstrated remarkable efficacy.…”
Gene therapy is a revolutionary treatment approach in the 21st century, offers significant potential for disease prevention and treatment. However, the efficacy of gene delivery is often compromised by the...
“…118,119 In addition, they also developed STING-activated spherical nucleic acids, which can effectively activate the cGAS-STING pathway to generate innate immune responses. 120 The development of SNAs that can activate the innate or adaptive immune system and elicit a potent anti-cancer immune response has demonstrated remarkable efficacy.…”
Gene therapy is a revolutionary treatment approach in the 21st century, offers significant potential for disease prevention and treatment. However, the efficacy of gene delivery is often compromised by the...
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