Immobilized Organocatalysts for Enantioselective Continuous Flow Processes

Rodríguez‐Escrich, Carles; Pericàs, Miquel À.

doi:10.1002/9783527832217.ch11

Cited by 3 publications

(3 citation statements)

References 141 publications

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“…When aiming at industrial applications, the immobilization of these catalysts onto suitable polymeric support offers several distinct advantages over their homogeneous counterparts. [9][10] This includes simplified workup procedures, the ability to easily separate and recover the supported systems from the reaction mixture, and the added convenience of recycling. [11] These advantages become especially important when dealing with enantioselective organocatalysts, which often require significant catalyst loading to achieve high levels of asymmetric induction.…”

Section: Introductionmentioning

confidence: 99%

Engineered Immobilised Organocatalysts for the Synthesis of Chiral Amines

Maciá,

Muñoz,

Porcar

et al. 2024

Adv Synth Catal

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Abstract. The art of tuning functional polymeric materials through the covalent incorporation of organocatalysts lies at the core of creating asymmetric immobilized chiral catalysts that mimic the enzymatic action. Herein, we explore diverse synthetic techniques to immobilize L‐proline‐derived N‐carbonyl amides on functional polymeric matrices, transforming them into chiral Lewis bases for facilitating the asymmetric reduction of ketimines with HSiCl3. A comprehensive examination of the design factors, encompassing linker selection, anions, and polymeric support characteristics, enables precise adjustment of steric and electronic features in these immobilized catalysts. This approach establishes structure‐performance relationships, ultimately enabling the development of an engineered immobilized organocatalytic system that meets the desired criteria for activity, stability, and selectivity.

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Section: Introductionmentioning

confidence: 99%

Engineered Immobilised Organocatalysts for the Synthesis of Chiral Amines

Maciá,

Muñoz,

Porcar

et al. 2024

Adv Synth Catal

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“…Immobilization of catalysts gained increasing traction over the last years. [20][21][22][23][24][25][26][27] In fact, many advantages arise from immobilization, including improved stability, reusability, and localization of the catalyst itself. Supported catalysts can be easily separated and removed from the products and the reaction medium.…”

Section: Introductionmentioning

confidence: 99%

“…Towards this aim, a collaboration between academia and industry was established to develop an alternative approach that addresses all these issues by exploiting immobilized catalysts. Immobilization of catalysts gained increasing traction over the last years [20–27] . In fact, many advantages arise from immobilization, including improved stability, reusability, and localization of the catalyst itself.…”

Section: Introductionmentioning

confidence: 99%

A Sustainable and Catalytic Synthesis of Dibenzosuberone

et al. 2023

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Dibenzosuberone (DBS) is a key intermediate for the synthesis of relevant active pharmaceutical ingredients (APIs) for the treatment of several diseases related to the central nervous system. Herein, the design and development of a milder and greener approach to improve the well-established methodology for the synthesis of DBS limiting waste production via the use of immobilized catalysts are presented.

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Flash Organometallic Catalysis Uncovered by Continuous Microfluidic Devices

Guan,

Wen

2024

ChemPlusChem

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The flash organometallic catalysis is a new concept that refers to the study of fast and controlled organometallic catalytic reactions by using microfluidic devices. Flash reactions’ kinetics (ms ‐ s scale) is often ignored due to the lack of proper research tool in organometallic chemistry. The development of microfluidic systems offers the opportunity to discover under‐studied mechanisms and new reactions. In this concept, the basic theory of kinetic measurement in a microreactor is briefly reviewed and then two examples on studying flash organometallic catalytic transformation are introduced. One example is the discovery of a highly active palladium catalytic species for Suzuki Coupling and the other example is the study of a neglected isomerization catalytic cycle with a time scale of seconds before isomerization‐hydroformylation by customized microfluidic devices. The last part is summary and prospect of this new area. Customizing a microfluidic device with good engineering design for a target reaction supports flash reactions’ kinetic experimentation and could become a general strategy in chemistry lab.

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Immobilized Organocatalysts for Enantioselective Continuous Flow Processes

Cited by 3 publications

References 141 publications

Engineered Immobilised Organocatalysts for the Synthesis of Chiral Amines

Engineered Immobilised Organocatalysts for the Synthesis of Chiral Amines

A Sustainable and Catalytic Synthesis of Dibenzosuberone

Flash Organometallic Catalysis Uncovered by Continuous Microfluidic Devices

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