Dibenzosuberone (DBS) is a key intermediate for the synthesis of relevant active pharmaceutical ingredients (APIs) for the treatment of several diseases related to the central nervous system. Herein, the design and development of a milder and greener approach to improve the well-established methodology for the synthesis of DBS limiting waste production via the use of immobilized catalysts are presented.
The Cover Feature shows the catalytic activity exerted by a minimalistic peptide behaving as an organocatalyst in a Michael addition. A supramolecular arrangement on the catalyst in fibrils showed to remarkably improve the TOF of the catalyst. The aldehyde donors and nitroalkenes acceptors are represented in the top left corner and are largely converted to the adduct as the reaction proceeds, towards the bottom right. Across the image the self‐assembled fibrils of a minimalistic tripeptide, catalyzing the reaction, are shown; the tripeptide is shown in detail, colored green, for one of the fibrils. Image credit: Nicola De Mitri. More information can be found in the Communication by A. Carlone et al.
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