Immobilization of yeast cells in acrylamide gel matrix

Aykut, G.; Hasırcı, Vasıf; Alaeddinoğlu, Gürdal

doi:10.1016/0142-9612(88)90117-2

Cited by 28 publications

(12 citation statements)

References 11 publications

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“…Hydrogels have been extensively studied and used for a large number of applications in the medical field, such as controlled drug release matrices, enzyme and yeast cell immobilization, blood-contacting applications, etc. [2,3]. The water content in the equilibrium of swelling affects different properties of the hydrogels: permeability, mechanical properties, surface properties, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Pulat

Çetin

2008

Journal of Bioactive and Compatible Polymers

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Poly(acrylamide-co-crotonic acid) (PAAmCA), poly(acrylic acidco-crotonic acid) (PAACA), PAA and PAAm hydrogels were prepared by free radical polymerization and ethylene glycol dimethacrylate (EGDMA) as a crosslinker. The variations of swelling values (%) with time, temperature, and pH were determined for four types of hydrogels. The PAACA hydrogel was swollen 2300% at pH ¼ 7.4 and 378C. The drug release from pantoprazole-Na loaded PAACA and PAAmCA hydrogels was followed at pH ¼ 7.4, 378C for 30 h. The release from PAACA hydrogel was faster than that from PAAmCA hydrogel; therapeutic levels for both hydrogels are obtained within 1 hour. Non-Fickian diffusion was determined for both hydrogels.

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Section: Introductionmentioning

confidence: 99%

Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Pulat

Çetin

2008

Journal of Bioactive and Compatible Polymers

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“…The extent of partition, on the other hand, is determined by the properties of the immobilization matrix. The parameters affecting the physical properties of polyacrylamide gel, which in turn affect the invertase activity of the entrapped yeast cells, were established by Aykut et al (1988). Invertase activity was found to increase with the water content of the matrix and decrease with increasing cell loadings.…”

Section: Immobilized Whole Microbial Cellsmentioning

confidence: 97%

Biotechnological Developments in Turkey

Özcengiz

1996

Critical Reviews in Biotechnology

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Turkey is a country not usually associated with industrial biotechnology. However, when current research potential in universities and other R & D centers and particularly contributions made to the international literature since the mid-1980s are taken into account, high-quality international-level work is now commonplace, especially in areas such as industrial microbiology, enzyme technology, biomaterials and biological wastewater treatment. Work in plant biotechnology is at a relatively early stage, but is expected to become a rapidly developing force in the near future. The present article documents current potential in Turkey, based on significant publications produced during the last 8 years.

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“…1 Hydrogels have been extensively studied and used for a large number of applications in medicine, such as controlled drug release matrices, 2,3 enzyme and yeast cell immobilization, 4 and blood-contact applications. 5 Interpenetrating polymer networks (IPNs) are mixtures of two crosslinked polymers.…”

Section: Introductionmentioning

confidence: 99%

Fluconazole release through semi‐interpenetrating polymer network hydrogels based on chitosan, acrylic acid, and citraconic acid

Pulat

Asıl

2009

J of Applied Polymer Sci

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Semi-interpenetrating polymer network hydrogels with different compositions of chitosan (Cs), acrylic acid, and citraconic acid were synthesized via freeradical polymerization with ethylene glycol dimethacrylate as a crosslinker. The variations of the swelling percentages of the hydrogels with time, temperature, and pH were determined, and Cs-poly(acrylic acid) (PAA) hydrogels were found to be most swollen at pH 7.4 and 37 C. Scanning electron micrographs of Cs-PAA and Cs-P(AA-co-CA)-1 (Cs-poly(acrylicacid-co-citraconir acid) À1 ) were taken to observe the morphological differences in the hydrogels. Although the less swollen hydrogel, Cs-P(AA-co-CA)-1, had a sponge-type structure, the most swollen hydrogel, Cs-PAA, displayed a uniform porous appearance. Fluconazole was entrapped in Cs-P(AA-co-CA)-1 and Cs-PAA hydrogels, and the release was investigated at pH 4.0 and 37 C. The kinetic release parameters of the hydrogels (the gel characteristic constant and the swelling exponent) were calculated, and non-Fickian diffusion was established for Cs-PAA, which released fluconazole much more slowly than the Cs-P(AA-co-CA)-1 hydrogel. A therapeutic range was reached at close to 1 h for both hydrogels.

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Immobilization of yeast cells in acrylamide gel matrix

Cited by 28 publications

References 11 publications

Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Biotechnological Developments in Turkey

Fluconazole release through semi‐interpenetrating polymer network hydrogels based on chitosan, acrylic acid, and citraconic acid

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