The drug adsorption and release characteristics of porous starches produced through hot air drying, spray drying, and vacuum freeze drying were investigated using ciprofloxacin as model drug. A UV/visible spectrophotometer, Fourier-transform infrared spectrometer, differential scanning calorimeter, and X-ray diffractometer were used to determine the drug adsorption/release, drug/ starch interaction, glass transition, and crystallinity of porous starch samples. The amount of ciprofloxacin adsorbed in three different porous starches was 5.58%, 8.91%, and 11.43%, respectively. The ciprofloxacin-loaded porous starches had glass-transition-related endothermic peaks between 55 C and 65 C and melting-related endothermic peaks between 120 C and 150 C. Up to 75% of the loaded ciprofloxacin was released from the freeze-dried sample within 30 hrs. The freeze-dried porous starch also showed higher ciprofloxacin loading rate, higher glass transition temperature, and higher ciprofloxacin release rate. A two-phase dynamic drug release model was found to satisfactorily fit the release kinetics of ciprofloxacin (R 2 > 0.995).