Immobilization of selenocystamine on TiO2 surfaces for in situ catalytic generation of nitric oxide and potential application in intravascular stents

Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography

“…http In addition to substrate topography, the biochemical cues presented on the BM also provide instructive signals to ECs. A number of biomolecules have been immobilized onto biomaterial surfaces to promote re-endothelialization [5][6][7], improve the blood compatibility [14,15] and inhibit SMC proliferation [16]. Heparin, the most widely used anticoagulant drug, has been immobilized on material surfaces to improve blood compatibility by increasing the affinity of antithrombin III to thrombin [14,17,18].…”

Nitric oxide based strategies for applications of biomedical devices

“…In vitro platelet adhesion results reveal that cystamine and Se modified surfaces can inhibit collagen-induced platelet activation through the NO/cGMP signal channel [164]. Moreover, in vivo studies have demonstrated that Se modified stents in femoral artery model after two months reduce the incidence of NIH, showing great promise for cardiovascular therapy [165]. Recently Zhilu Yang et al have reported a NO-catalytic bioactive coating obtained by covalent conjugation of 3,3-diselenodipropionic acid (SeDPA) to generate NO from RSNOs (Fig.…”

“…Yajun Weng et al have immobilized cystamine and selenocystamine (Se) on TiO 2 surface for catalytic generation of NO [164,165]. In vitro platelet adhesion results reveal that cystamine and Se modified surfaces can inhibit collagen-induced platelet activation through the NO/cGMP signal channel [164].…”

Reduced platelet adhesion and improved corrosion resistance of superhydrophobic TiO2-nanotube-coated 316L stainless steel

“…The platelet adhesion experiment on different samples was performed to preliminarily evaluate the blood compatibility. Adherent platelet shapes are classified into five categories according to activation [58,59]: round, dendritic, spread dendritic, spreading and fully spreading. Fig.…”