Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices—Enhanced stability and release

Valo, Hanna; Kovalainen, Miia; Laaksonen, Päivi; Häkkinen, Merja R.; Auriola, Seppo; Peltonen, Leena; Linder, Markus B.; Järvinen, Kristiina; Hirvonen, Jouni; Laaksonen, Timo

doi:10.1016/j.jconrel.2011.07.016

Cited by 133 publications

(76 citation statements)

References 35 publications

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“…An example of topical drug delivery using hydrophobins is formulation of the drug terbinafine which enhances the permeation of terbinafine through human nails (Vejnovic et al 2010b). Instead of directly coating drug nanoparticles, hydrophobins can also be used to modify the surface stability and biocompatibility of already existing drug-loaded particles of porous silicon (Bimbo et al 2011) and cellulose (Valo et al 2011(Valo et al , 2013.…”

Section: Dispersal Of Hydrophobic Solids Liquids and Airmentioning

confidence: 99%

Applications of hydrophobins: current state and perspectives

Wösten

Scholtmeijer

2015

Appl Microbiol Biotechnol

133

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Hydrophobins are proteins exclusively produced by filamentous fungi. They self-assemble at hydrophilichydrophobic interfaces into an amphipathic film. This protein film renders hydrophobic surfaces of gas bubbles, liquids, or solid materials wettable, while hydrophilic surfaces can be turned hydrophobic. These properties, among others, make hydrophobins of interest for medical and technical applications. For instance, hydrophobins can be used to disperse hydrophobic materials; to stabilize foam in food products; and to immobilize enzymes, peptides, antibodies, cells, and anorganic molecules on surfaces. At the same time, they may be used to prevent binding of molecules. Furthermore, hydrophobins have therapeutic value as immunomodulators and can been used to produce recombinant proteins.

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Section: Dispersal Of Hydrophobic Solids Liquids and Airmentioning

confidence: 99%

Applications of hydrophobins: current state and perspectives

Wösten

Scholtmeijer

2015

Appl Microbiol Biotechnol

133

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“…6 NFs can also be used for the controlled release of compounds by protecting and stabilizing the compound, being slowly released under suitable conditions. 7 Cellulose, which is a relatively stable polymer with hydrogen bonding, serves as a good source of NFs. Cellulose nanofibers (CNFs) possess several advantages such as good flexibility, good elasticity, low density, low toxicity and a relatively reactive surface that can be used for grafting specific groups, in addition to being renewable and cheap.…”

mentioning

confidence: 99%

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

141

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Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%±1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%±2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%±2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

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“…[47] Indeed, CNF has been investigated to replace the nucleus pulposus (inner core of the vertebral disc) as well as to stabilize and control the delivery of protein-coated drugs. [48,49]. But their usefulness goes beyond exploiting their electrical reactance in electrical circuits.…”

Section: Cellulose Nanofibersmentioning

confidence: 99%

Upscaling Organic Electronic Devices

Malti¹

2015

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Conventional electronics based on silicon, germanium, or compounds of gallium require prohibitively expensive investments. A state-of-the-art microprocessor fabrication facility can cost up to $15 billion while using environmentally hazardous processes. In that context, the discovery of solution-processable conducting (and semiconducting) polymers stirred up expectations of ubiquitous electronics because it enables the mass-production of devices using well established high-volume printing techniques. In essence, this thesis attempts to study the characteristics and applications of thin conducting polymer films (<200 nm), and scale them up to thick-films (>100 µm). First, thin-films of organic materials were combined with an electric double layer capacitor to decrease the operating voltage of organic field effect transistors. In addition, ionic current-rectifying diodes membranes were integrated inside electrochromic displays to increase the device's bistability and obviate the need for an expensive addressing backplane.This work also shows that it is possible to forgo the substrate and produce a self-standing electrochromic device by compositing the same water-processable material with nanofibrillated cellulose (plus a whitening pigment and high-boiling point solvents). In addition, we investigated the viability of these (semi)conducting polymer nanopaper composites in a variety of applications. This material exhibited an excellent combined electronic-ionic conductivity. Moreover, the conductivities in this easy-to-process composite remained constant within a wide range of thicknesses. Initially, this (semi)conducting nanopaper composite was used to produce electrochemical transistors with a giant transconductance (>1 S). Subsequently, it was used as electrodes to construct a supercapacitor whose capacitance exceeds 1 F.

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Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices—Enhanced stability and release

Cited by 133 publications

References 35 publications

Applications of hydrophobins: current state and perspectives

Applications of hydrophobins: current state and perspectives

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Upscaling Organic Electronic Devices

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