Immobilization of Penicillium chrysogenum: spore growth on Celite

Isolation and partial purification of a metabolite from a mutant strain of Bacillus sp. with antibiotic activity against plant pathogenic agents

“…For decades, penicillin yields have been increased through development of better production strains by classical mutagenesis procedures and optimization of the growth conditions (Vanek and Hostalek, 1986;Fernandez-Canon et al 1989;Keshavarz et al 1989). Currently, together with * Corresponding autor molecular techniques, this facilitated a thorough analysis of the genetic regulation of metabolic pathways.…”