Immobilization of nano Cu-MOFs with polydopamine coating for adaptable gasotransmitter generation and copper ion delivery on cardiovascular stents

Fan, Yunge; Zhang, Yu; Zhao, Qian; Xie, Yinhong; Luo, Rifang; Yang, Ping; Weng, Yajun

doi:10.1016/j.biomaterials.2019.03.007

Cited by 109 publications

(68 citation statements)

References 44 publications

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“…Furthermore, if Cu ion or complex combined with proteins or its receptor, which will inhibit platelet and cell adhesion to the material's surface. There was a new research on the stent with nano Cu‐MOFs with polydopamine coating, which inhibited thrombosis, intimal hyperplasia, and accelerate re‐endothelialization (Fan et al, 2019). In the platelet adhesion test part, the nano Cu‐MOFs‐immobilized coating exhibited desirable NO release and adaptable Cu 2+ delivery.…”

Section: Discussionmentioning

confidence: 99%

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

et al. 2020

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Vascular implant interventional medical catheter will contact with blood firstly after implantation. The anticoagulation and antibacterial functions of this device will determine the success or failure. Copper (Cu) has been verified to possess multi‐biofunctions, but it was challenging to add the Cu metal to most materials. Take advantage of its functionality; Cu has been grafted on the material surface to improve the anticoagulation function and accelerate endothelialization. In this study, a Cu‐bearing chitosan coating was prepared on the catheter to endow the anticoagulation and anti‐infection functions. Besides, properties characterization and functional evaluation of the coated medical catheter were investigated. Dynamic blood clotting and platelet adhesion tests were carried out to evaluate the anticoagulation property. Besides this, the antibacterial test was used to estimate the anti‐infection function. The surface energy and Cu ions release from the coating were detected and calculated by contact angles and immersion tests, respectively. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR) and X‐ray photoelectron spectroscopy (XPS) revealed that Cu ions were grafted in the chitosan coating. Thermogravimetric analysis (TA) result showed the concentration of Cu ions in the coating. The results of dynamic blood clotting, platelet adhesion, and antibacterial tests revealed that Cu grafted in chitosan would improve the blood compatibility and anti‐infection property. The surface properties and Cu ions release behavior of Cu‐bearing coating revealed the reasons for multi‐biofunctions. This study indicated that the Cu‐bearing chitosan coating could endow the vascular implant interventional device anticoagulation and anti‐infection functions, which has excellent potential for clinical application.

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Section: Discussionmentioning

confidence: 99%

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

et al. 2020

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“…Inspired by the properties of PDA film, which exhibits strong adhesion to almost any substrate via covalent and/or non‐covalent interactions, [ 117 ] Yajun Weng and colleagues used PDA as the linker and coating matrix to immobilize nanoscale copper‐based MOF onto the titanium surface for simultaneous NO catalytic generation by decomposing endogenous snitrosothiols. [ 118 ] Inhibited platelet aggregation, reduced thrombosis, and promoted EC proliferation were achieved using such coating. However, it is hard to control the amount of endogenous Snitrosothiols around the coating stents, leading to the poor controllability in NO release and suboptimal therapeutic effect of NO.…”

Section: The Biomedical Applications Of Polymeric No Delivery Nanoplamentioning

confidence: 99%

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.

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“…For example, the arterial endothelium produces NO, which can induce vasodilation (Olver et al, ). Moreover, NO affects the cardiovascular system by inhibiting platelet activation, anti‐atherosclerotic effects, and SMC proliferation (Fan et al, ). Furthermore, there were many other endothelium‐derived factors, such as PGI2, EDHF, and ET‐1(Figure ), which can affect the function of SMCs (Vanhoutte, ).…”

Section: Discussionmentioning

confidence: 99%

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

Tan

Cui

Zeng

et al. 2020

J Biomedical Materials Res

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The rapid re‐endothelialization of the vascular stent surface is desirable for preventing thrombosis or reducing restenosis. Many biological factors that promote the biological behavior of endothelial cells have been used for the surface modification of stents. Vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, induces strong vascular growth. In this study, we investigated different VEGF concentrations (50 to 500 ng/ml) to determine the optimum concentration for biocompatibility. First, VEGF‐loaded heparin/poly‐l‐lysine (Hep‐PLL) nanoparticles were created by electrostatic interactions. Then, the VEGF‐loaded nanoparticles were immobilized on dopamine‐coated 316 L stainless steel (SS) surfaces. The physical and chemical properties of the modified surface were characterized and the biocompatibility was evaluated in vitro. The results indicated that the VEGF‐loaded nanoparticles were immobilized successfully on the 316LSS surface, as evidenced by the results of Alcian Blue staining and water contact angle (WCA) measurements. The low platelet adhesion and activation indicated that the modified surfaces had good blood compatibility. The modified surfaces showed a good inhibitory effect on smooth muscle cells, indicating that they inhibited tissue hyperplasia. In addition, the modified surfaces significantly promoted endothelial cell adhesion, proliferation, migration, and biological activity, especially VEGF concentration was 350 ng/ml (NPV350). The optical VEGF concentration of the surface modified Hep‐PLL nanoparticles was 350 ng/ml. The proposed method shows promise for potential applications for cardiovascular devices.

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Immobilization of nano Cu-MOFs with polydopamine coating for adaptable gasotransmitter generation and copper ion delivery on cardiovascular stents

Cited by 109 publications

References 44 publications

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

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