Immobilization of l-alanine into natural kaolinite via amidation catalyzed by boric acid for the development of biohybrid materials

Silva, Alexandre Fernando da; Pádua, G.S. de; Araújo, Denis Talarico de; Vieira, Carlos Alexandre; Faria, Emerson H. de

doi:10.1016/j.jssc.2020.121332

Cited by 9 publications

(5 citation statements)

References 59 publications

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“…MeOH modification can be used as an intermediate to prepare Kaol‐APTES, [ 123 ] which has a high affinity and adsorption capacity of Kaol‐APTES with acetylsalicylic acid and ibuprofen: 10.20 mg g −1 for Kaol against 210.30 mg g −1 for Kaol‐APTES, thus affirming the drug adsorption enhancement by grafting modification (Figure 6c ). [ 122 ]…”

Section: Regulation Strategies Of Kaolmentioning

confidence: 99%

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review

Liao

Yang

2023

Advanced Science

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Advanced functional two‐dimensional (2D) nanomaterials offer unique advantages in drug delivery systems for disease treatment. Kaolinite (Kaol), a nanoclay mineral, is a natural 2D nanomaterial because of its layered silicate structure with nanoscale layer spacing. Recently, Kaol nanoclay is used as a carrier for controlled drug release and improved drug dissolution owing to its advantageous properties such as surface charge, strong biocompatibility, and naturally layered structure, making it an essential development direction for nanoclay‐based drug carriers. This review outlines the main physicochemical characteristics of Kaol and the modification methods used for its application in biomedicine. The safety and biocompatibility of Kaol are addressed, and details of the application of Kaol as a drug delivery nanomaterial in antibacterial, anti‐inflammatory, and anticancer treatment are discussed. Furthermore, the challenges and prospects of Kaol‐based drug delivery nanomaterials in biomedicine are discussed. This review recommends directions for the further development of Kaol nanocarriers by improving their physicochemical properties and expanding the bioapplication range of Kaol.

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Section: Regulation Strategies Of Kaolmentioning

confidence: 99%

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review

Liao

Yang

2023

Advanced Science

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“…They range from systems in which the association between both components ends in a single hybrid phase to intimate combinations of different organic and inorganic materials. The interaction between organic with inorganic matrixes generates synergistic effects in the new structures, resulting in multifunctional materials with unique properties that could improve the physical characteristics from original constituents, even capable of overcoming the structural limitations of conventional materials [5,6]. These properties provide a variety of potential applications in multiple fields, especially for pharmaceutical and biomedical areas such as controlledrelease agents for drug delivery [7].…”

Section: Introductionmentioning

confidence: 99%

“…Among these, layered double hydroxides (LDH) have attracted considerable interest in preparing controlled-release formulations mainly for two reasons: the surface load of the clay mineral and the ability to modify the interlaminar space [8,9]. Many organic molecules have combined with these anionic clays, e.g., antioxidants, amino acids, polymers, and vitamins [6,[10][11][12]. LDH structure has been known since 150 years ago and are formed by stacked brucite-like layers and interlayer regions or galleries.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Organic-Inorganic Hybrid Material with a Synergistic Interface as a Release Agent for Free Acid β-Hydroxy-β-Methyl Butyrate

Andrade-Espinoza¹,

Arízaga

Rivas-Fuentes

et al. 2021

Journal of Nanomaterials

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We report the preparation and characterization of a new organic-inorganic hybrid system composed of type-I collagen and ZnAl layered double hydroxide (LDH) particles loaded with β-hydroxy-β-methyl butyrate (HMB) by coprecipitation reaction. X-ray diffraction (peaks well agree with those reported in the literature), infrared spectroscopy (stretching bonds for both organic-inorganic compounds), and X-ray photoelectron spectroscopy confirmed the hybrid system retained HMB in the carboxylate form, and a small fraction turned to the acid form. In both cases, the HMB molecules are assembled to the LDH surface. The hybrid compound results in improved thermal stability for HMB and collagen, as shown by thermal analysis. Scanning electron microscopy data reflects different arrangements from LDH sheets with interesting physicochemical properties since LDH and collagen protect free HMB and make it more bioavailable and functional. In vitro studies as part of high-throughput screening strategies indicated that LDH hybrids reduced cell viability around 75-90%, which is an acceptable viability value because of the L6 cell line susceptibility. However, all new nanomaterials must be carefully analyzed by different toxicity tests because a single test does not evaluate complete physiological compartments.

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“…En las últimas dos décadas, nanomateriales híbridos orgánicos/inorgánicos han alcanzado un desarrollo intensivo para establecer modalidades de entrega de sustancias eficaces (da Silva et al, 2020). El desarrollo de estos sistemas es posible gracias a la interacción entre la matriz inorgánica con la molécula orgánica, la cual genera efectos sinérgicos en las nuevas estructuras y da lugar a materiales con propiedades únicas que podrían resultar en una mejora de las características de los constituyentes originales (Fernandes y Baradari, 2014).…”

Section: Introductionunclassified

Evaluación genotóxica de un novedoso nanohíbrido para la liberación de moléculas bioactivas

Arratia-Quijada

Andrade-Espinoza

Nuño-Anguiano

et al. 2021

ICBI

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En las últimas dos décadas, los nanomateriales híbridos orgánicos-inorgánicos han alcanzado un desarrollo intensivo. Sin embargo, antes de su posible aplicación, se requiere de una evaluación completa y adecuada tanto de sus propiedades fisicoquímicas y beneficios, como de los potenciales efectos tóxicos para la salud humana. El objetivo de este estudio fue determinar el potencial genotóxico in vivo de nanohíbridos diseñados a base de hidróxidos dobles laminares/ß-hidroxi-ß-metil butirato/colágeno (ZnAl/HMB/Col) tras una exposición oral aguda. El potencial genotóxico fue evaluado en ratas macho Sprague-Dawley (SD) de 9 semanas de edad tras 7 días continuos de exposición oral a los nanohíbridos, a una dosis de 2,000 mg/kg. No se observó una diferencia estadísticamente significativa entre el número de micronúcleos (MN) y la administración de los tratamientos sobre los valores del grupo control.

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Immobilization of l-alanine into natural kaolinite via amidation catalyzed by boric acid for the development of biohybrid materials

Cited by 9 publications

References 59 publications

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review

Synthesis of Organic-Inorganic Hybrid Material with a Synergistic Interface as a Release Agent for Free Acid β-Hydroxy-β-Methyl Butyrate

Evaluación genotóxica de un novedoso nanohíbrido para la liberación de moléculas bioactivas

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