Immobilization of carboranes on Fe3O4-polymer nanocomposites for potential application in boron neutron cancer therapy

Boron and Gadolinium Loaded Fe3O4 Nanocarriers for Potential Application in Neutron Capture Therapy

“…In addition, the characterization of these structures by methods of roentgen di fraction was obstructed due to the hashing of peaks characteristic for Fe3O4 and FeO•Fe2O and some nonstoichiometric phases that can appear while the synthesis process. In som works [29,44], for a proper characterization and estimation of the phase content of Fe3O nanoparticles synthesized using the wet chemical method, a combined roentge These peaks are related to the Fe 3 O 4 phase and characterized by Miller indexes (220) and (442). As the literature shows, nanostructural Fe 3 O 4 is distinguished by its high content of disordered regions due to the big concentration of vacancy defects in structure [42,43].…”

“…In addition, the characterization of these structures by methods of roentgen diffraction was obstructed due to the hashing of peaks characteristic for Fe 3 O 4 and FeO•Fe 2 O 3 and some nonstoichiometric phases that can appear while the synthesis process. In some works [29,44], for a proper characterization and estimation of the phase content of Fe 3 O 4 nanoparticles synthesized using the wet chemical method, a combined roentgen diffraction and Mössbauer spectroscopy method was used. This method is more sensitive to the division of different phases contribution because values characteristic for hyperfine fields are significantly different.…”

“…The toxicity of carborane compound is incomparably small compared to the studied nanoparticles, although a greater sensitivity is also observed in cancer cell lines. It is also known that iron oxide nanoparticles modified by various methods have low toxicity [29,65]. In case Fe 3 O 4 /TEOS/TMSPM/GMA/Carborane the cytotoxicity was low and the IC 50 was impossible to determine [29].…”

“…Zhu et al declare the concentration of delivered boron through magnetic nanoparticles to be 51.4 µg/g [28]. A higher concentration of NCT agents can be achieved by covering the magnetic nanoparticle with polymer to make the surface's structure branched [29]. Gd ions can be immobilized via chelate complexes, such as Gd-pentaacetate (Gd-DTPA) [30].…”

The impact of temperature on electrical properties of polymer-based nanocomposites

“…Such hybrid materials are of great practical interest because of their improved thermal conductivity, radiation resistance, electrical insulation of thermoplastics, and thermal performance [5][6][7][8][9]. Obtained hybrid nanocomposites based on organic semiconductors, ferroelectric and magnetic materials are used in light emitting devices, lighting holders, various electronic devices, motors and battery casing, temperature sensors and optimized heat exchangers [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”