Boron and Gadolinium Loaded Fe3O4 Nanocarriers for Potential Application in Neutron Capture Therapy

Abstract

In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 nanoparticles were treated with silane and then the polyelectrolytic layer was formed for further immobilization of NCT agents. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray (EDX), ultraviolet–visible (UV-Vis) and Mössbauer spectroscopies, dynamic light scattering (DLS), scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) were applied for the characterization of the chemical and element composition, structure, morphology and magnetic properties of nanocarriers. The cytotoxicity effect was evaluated on different cell lines: BxPC-3, PC-3 MCF-7, HepG2 and L929, human skin fibroblasts as normal cells. average size of nanoparticles is 110 nm; magnetization at 1T and coercivity is 43.1 emu/g and 8.1, respectively; the amount of B is 0.077 mg/g and the amount of Gd is 0.632 mg/g. Successful immobilization of NCT agents, their low cytotoxicity against normal cells and selective cytotoxicity against cancer cells as well as the superparamagnetic properties of nanocarriers were confirmed by analyses above.

Importance of precursor complexation for green solvent‐processed perovskite crystals

“…[35][36][37] FTIR spectra were measured to understand the aging effect in the precursor solution. In Figure 2a the observed peaks at 1542.022 cm À1 and 1711.751 cm À1 correspond to COO À antisymmetric stretch (COO À as ) and C O stretch vibration, respectively, [38][39][40][41] being ascribed to the carboxylate of propionate in MAP. 42 It is noted that the peak corresponding to C N stretch vibration undergoes a blue shift from 1625.922 cm À1 for the as-prepared precursor solution (0 h) to 1637.494 cm À1 for the aged solution (80 h).…”

Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

“…Moreover, Korolkov and his group [ 78 ] developed a Fe-B-Gd nanosystem obtained by B and Gd immobilization on the Fe 3 O 4 NP surface, through the alkaline coprecipitation method. The coating was performed by reacting the iron oxide NPs with 3-(trimethoxysilyl)propyl methacrylate followed by acrylic acid, thus introducing the carboxylic groups that, together with poly(allylamine), coordinate Gd ions; finally, through the formation of a second polyelectrolyte layer via subsequent reactions with poly(acrylic acid) and poly(allylamine), the 3-(isopropyl- o -carboranyl) hydrindone was attached.…”

“…Moreover, Korolkov and his group [78] developed a Fe-B-Gd nanosystem obtained by B and Gd immobilization on the Fe 3 O 4 NP surface, through the alkaline coprecipitation method.…”

Simultaneous Immobilization of Gadolinium Ions and Di(o-carborano-1,2-dimethyl)borate on Fe3O4 Nanoparticles

“…To treat cancer with this method, a drug labeled with specific isotopes (usually 10 B and 157 Gd) is delivered to the tumor. After that, it is irradiated with epithermal neutron flux.…”