Immersion vaccination of Mandarin fish Siniperca chuatsi against infectious spleen and kidney necrosis virus with a SWCNTs-based subunit vaccine

Zhao, Zhao; Zhang, Chen; Jia, Yijun; Qiu, De-Kui; Lin, Qiang; Li, Ningqiu; Huang, Zhibin; Fu, Xiaozhe; Wang, Gao‐Xue; Zhu, Bin

doi:10.1016/j.fsi.2019.06.001

Cited by 32 publications

(22 citation statements)

References 35 publications

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“…There is no effective vaccine against this fatal disease at present. The effect of an immersion subunit vaccine system (SWCNTs-major capsid protein (MCP)) encoding MCP gene of ISKNV based on single-walled carbon nanotubes (SWCNTs) was determined [118]. Juvenile Mandarin fish weighing 6 g were vaccinated via bath administration for 10 h. On the 28th day post-vaccination, fish were challenged by intraperitoneal injection with 50 µL of 3.98 × 10 6 TCID 50 mL −1 live ISKNV.…”

Section: Infectious Spleen and Kidney Necrosis Virusmentioning

confidence: 99%

Review on Immersion Vaccines for Fish: An Update 2019

Bøgwald

Dalmo

2019

Microorganisms

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Immersion vaccines are used for a variety of aquacultured fish to protect against infectious diseases caused by bacteria and viruses. During immersion vaccination the antigens are taken up by the skin, gills or gut and processed by the immune system, where the resulting response may lead to protection. The lack of classical secondary responses following repeated immersion vaccination may partly be explained by the limited uptake of antigens by immersion compared to injection. Administration of vaccines depends on the size of the fish. In most cases, immersion vaccination is inferior to injection vaccination with regard to achieved protection. However, injection is problematic in small fish, and fry as small as 0.5 gram may be immersion vaccinated when they are considered adaptively immunocompetent. Inactivated vaccines are, in many cases, weakly immunogenic, resulting in low protection after immersion vaccination. Therefore, during recent years, several studies have focused on different ways to augment the efficacy of these vaccines. Examples are booster vaccination, administration of immunostimulants/adjuvants, pretreatment with low frequency ultrasound, use of live attenuated and DNA vaccines, preincubation in hyperosmotic solutions, percutaneous application of a multiple puncture instrument and application of more suitable inactivation chemicals. Electrostatic coating with positively charged chitosan to obtain mucoadhesive vaccines and a more efficient delivery of inactivated vaccines has also been successful.

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Section: Infectious Spleen and Kidney Necrosis Virusmentioning

confidence: 99%

Review on Immersion Vaccines for Fish: An Update 2019

Bøgwald

Dalmo

2019

Microorganisms

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“…The efficacy of antiviral vaccines administered by bath to induce B and T cell responses has been also demonstrated in fish ( 80 – 82 ). For instance, a significant specific antibody response was detected in carp 28 and 36 days after bath vaccination for 30 min with a KHV vaccine which consisted in inactivated Escherichia coli expressing glycoprotein-25 ( 80 ).…”

Section: Local and Systemic Effects After Immersion Vaccinationmentioning

confidence: 99%

“…For instance, a significant specific antibody response was detected in carp 28 and 36 days after bath vaccination for 30 min with a KHV vaccine which consisted in inactivated Escherichia coli expressing glycoprotein-25 ( 80 ). In another study, carbon nanotubes were tested as vaccine carriers to enhance the efficacy of an immersion vaccine ( 81 , 82 ). Specifically, functionalized single-walled carbon nanotubes (SWCNTs) used as carriers of a DNA vaccine encoding a matrix protein of SVCV and expressing a green fluorescent protein (pEGFP-M) produced a significant increase of antibody levels and an upregulation of IgM, IgZ1, CD8β, CD4, MHC I, and MHC II transcription levels in carp immunized by bath twice for 10 h after a 3 day interval ( 81 ), suggesting the activation of both cytotoxic and helper T lymphocytes upon immunization.…”

Section: Local and Systemic Effects After Immersion Vaccinationmentioning

confidence: 99%

“…Specifically, functionalized single-walled carbon nanotubes (SWCNTs) used as carriers of a DNA vaccine encoding a matrix protein of SVCV and expressing a green fluorescent protein (pEGFP-M) produced a significant increase of antibody levels and an upregulation of IgM, IgZ1, CD8β, CD4, MHC I, and MHC II transcription levels in carp immunized by bath twice for 10 h after a 3 day interval ( 81 ), suggesting the activation of both cytotoxic and helper T lymphocytes upon immunization. Similarly, bath vaccination of Mandarin fish ( Siniperca chuatsi ) for 10 h with a subunit vaccine system encoding the major capsid protein (MCP) of the infectious spleen and kidney necrosis virus (ISKNV) based on SWCNTs produced higher levels of antibody as well as higher IgM mRNA levels than those obtained in groups vaccinated with the naked vaccine ( 82 ).…”

Section: Local and Systemic Effects After Immersion Vaccinationmentioning

confidence: 99%

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Systemic and Mucosal B and T Cell Responses Upon Mucosal Vaccination of Teleost Fish

Muñoz-Atienza¹,

Díaz‐Rosales²,

Tafalla³

2021

Front. Immunol.

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The development of mucosal vaccines against pathogens is currently a highly explored area of research in both humans and animals. This is due to the fact that mucosal vaccines have the potential to best elicit protective responses at these mucosal surfaces, which represent the frontline of host defense, thus blocking the pathogen at its initial replication sites. However, in order to provide an efficient long-lasting protection, these mucosal vaccines have to be capable of eliciting an adequate systemic immune response in addition to local responses. In aquaculture, the need for mucosal vaccines has further practical implications, as these vaccines would avoid the individual manipulation of fish out of the water, being beneficial from both an economic and animal welfare point of view. However, how B and T cells are organized in teleost fish within these mucosal sites and how they respond to mucosally delivered antigens varies greatly when compared to mammals. For this reason, it is important to establish which mucosally delivered antigens have the capacity to induce strong and long-lasting B and T cell responses. Hence, in this review, we have summarized what is currently known regarding the adaptive immune mechanisms that are induced both locally and systemically in fish after mucosal immunization through different routes of administration including oral and nasal vaccination, anal intubation and immersion vaccination. Finally, based on the data presented, we discuss how mucosal vaccination strategies could be improved to reach significant protection levels in these species.

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“…This nanomaterial has been used in aquatic animal vaccines, which can significantly improve the delivery efficiency of DNA vaccines and delay the degradation time of plasmids in the body (Zhang et al, 2018;Zhao et al, 2019;Zhu et al, 2020), and the issue of CNT potential toxicity has been investigated .…”

mentioning

confidence: 99%

Immersion immunization of common carp with bacterial ghost‐based DNA vaccine inducing prophylactic protective immunity against spring viraemia of carp virus

Zheng

Zhang

et al. 2021

Journal of Fish Diseases

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Aquaculture products represent a key component of world trade (Naylor et al., 2000). According to the State of World Fisheries and Aquaculture 2020 report released by the FAO, the data showed that global aquaculture production reached 82.1 million tons in 2018, accounting for 46% of total aquatic products. Nevertheless, the frequent outbreak of infectious disease in aquatic animal has attracted more and more public attention on the development of aquaculture fishery (Gao et al., 2020). OIE has listed the spring viraemia of carp (SVC) as one of the animal diseases as notifiable (Ashraf et al., 2016). This disease usually breaks out with the spring and causes a large number of deaths in young fish once infected (Kanellos et al., 2006).Researchers have been working to find effective ways to prevent and control spring viraemia of carp virus (SVCV), but there is no approved treatment (Boonthai et al., 2017).

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Immersion vaccination of Mandarin fish Siniperca chuatsi against infectious spleen and kidney necrosis virus with a SWCNTs-based subunit vaccine

Cited by 32 publications

References 35 publications

Review on Immersion Vaccines for Fish: An Update 2019

Review on Immersion Vaccines for Fish: An Update 2019

Systemic and Mucosal B and T Cell Responses Upon Mucosal Vaccination of Teleost Fish

Immersion immunization of common carp with bacterial ghost‐based DNA vaccine inducing prophylactic protective immunity against spring viraemia of carp virus

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