Immediate effects of diamond burr debridement in patients with spontaneous chronic corneal epithelial defects, light and electron microscopic evaluation

Abstract

DBD significantly reduces the superficial stromal HAZ in SCCEDs. A reduction of its thickness may be responsible for the healing rates reported with DBD.

Treatment of spontaneous chronic corneal epithelial defects (SCCEDs) with diamond burr debridement vs combination diamond burr debridement and superficial grid keratotomy

“…Of the 20 eyes that underwent DBD+SGK for the first treatment and did not heal at the second recheck, 2 eyes received a DBD resulting in 50.0% of SCCEDs healed by the third recheck visit (15.0 AE 2.8 days from the second treatment to the third recheck visit, range [13][14][15][16][17]. Of the 5 eyes treated medically at the second treatment regardless of whether DBD or DBD+SGK was performed as the first treatment, 100% had healed by the third recheck visit (20.6 AE 9 days from the second treatment to the third recheck visit, range [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

“…23 A recent study using light and electron microscopy following DBD showed significant changes in the superficial stromal hyalinized acellular zone (HAZ) that may be responsible for the high healing rates associated with DBD alone. 24 Determining the most efficient and effective treatment for canine SCCEDs remains an ongoing goal in veterinary ophthalmology. With many treatment modalities currently available, the goal is to establish a treatment method or combination of methods that provide the highest success rate of SCCED healing with minimal post-treatment complications.…”

“…The hypothesis was that combination DBD+SGK would increase the overall healing rates compared with DBD alone as it was predicted that DBD+SGK may disrupt the HAZ more effectively than DBD alone. 14,24 Secondary objectives included the evaluation of signalment, medical history, subsequent treatments, and concurrent topical therapy that may influence healing. Investigation into a possible relationship between post-treatment complications and the treatment method after the first treatment was also evaluated.…”

Diamond burr debridement vs. grid keratotomy in canine SCCED with scanning electron microscopy diamond burr tip analysis

“…Therapeutic interventions are aimed at removing the redundant epithelium and debriding the anterior acellular stromal layer of the abnormal cornea . Epithelial debridement using cotton‐tipped applicators (e.g., Q‐tips, IND‐SWIFT Laboratories Inc., Dover, Delaware, USA) can be a sole therapy, and is also the initial step in most other treatments of SCCED .…”

Comparison of two cleaning and sterilization protocols of diamond burr tips used in debridement for canine superficial chronic corneal epithelial defects

“…5 While various different therapies have been reported to treat canine SCCED, the newest form of surgical treatment is diamond burr debridement (DBD) following routine cotton tip applicator debridement. 2,[6][7][8][9][10][11] In veterinary ophthalmology, DBD involves the use of a 3.5-mm medium-grit diamond burr tip (DBT) attached to a battery-powered motorized handpiece on exposed stoma and surrounding corneal epithelium. Studies have suggested faster healing times than other therapeutic interventions, especially when combined with a bandage contact lens.…”