Treatment of spontaneous chronic corneal epithelial defects (SCCEDs) with diamond burr debridement vs combination diamond burr debridement and superficial grid keratotomy

Abstract

DBD and DBD+SGK are equally effective treatment methods for canine SCCEDs. No differences in complication rates after one treatment were observed between DBD and DBD+SGK.

Cotton‐tip debridement, scalpel blade debridement, and superficial grid keratotomy for treatment of spontaneous chronic corneal epithelial defects (SCCED): A retrospective evaluation of 308 cases

“…The results of this study show that one CTD + SBD + SGK treatment yields a higher healing rate and lower healing time (97.1% healed, 11.5 days ± 6.6 days) than the ones reported by Wu et al 6 after one combined use of diamond burr debridement and superficial grid keratotomy (77.3% healed, 15.4 ± 5.0 days), by Stanley et al 18 after one superficial grid keratotomy (75% healed, 13.4 ± 5.1 days), and by Hung et al 23 after a diamond burr debridement (73.9% healed, 15.7 ± 4.9 days). However, healing time in this study was higher than the one obtained by Wooff et al 14 on a population of 27 Boxers after a similar corneal debridement technique followed by a linear grid keratotomy with (7.0 days) or without (10.0 days) the use of a corneal bandage contact lens.…”

“…It has been postulated that techniques addressing the abnormal basement membrane and the thin superficial acellular zone of hyaline collagen in the anterior stroma promote epithelial adhesions and extracellular matrix modulation. 2,3,6,18,21 Diamond burr debridement effectively removes the epithelium and has been shown to significantly reduce the thickness of the hyaline acellular membrane. It has also been demonstrated that this layer can be partially or completely removed when the diamond burr debridement was performed for 45-60 seconds.…”

“…7 Since then, several reports demonstrated that treatments addressing the abnormal stroma have a higher healing rate than epithelial debridement alone by providing a healthy substrate for epithelial adhesion. [2][3][4]6,7,14,18,19 The technique of epithelial debridement using a scalpel blade followed by a linear grid keratotomy was reported by Wooff et al in 2015, who reported a healing rate of 100% after one procedure. 14 The purpose of this study is to evaluate the clinical course and outcome of canine SCCEDs treated with a combination of cotton-tip debridement, scalpel blade debridement, and superficial grid keratotomy (CTD + SBD + SGK).…”

Breed prevalence of canine ulcerative keratitis according to depth of corneal involvement

“…For these reasons, BC dogs may be more prone to bacterial contamination leading to complicated UK. 17,18 With respect to the age distribution for each grade (Figure 4), a peak of frequency distribution of UK occurred in Grade 1 around the middle age, which is consistent with previous reports [19][20][21][22][23][24][25] with respect to dogs affected by SCCEDs. Interestingly, among BC breeds, bimodal peaks were observed in Grade 3 UK.…”

Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs

“…Because the ECM is altered during the progression of both the bullous keratopathy and the SCCED, multiple treatment modalities have been considered. The management of SCCED treatments include medical therapies such as polysulfated glycosaminoglycans (PSGAGs), protease MMP inhibitors, topical epidermal growth factors, fibronectin and surgical therapy with epithelial debridement, especially diamond burr debridement (DBD), which is now becoming the standard but associated to medical therapies to enhance the healing process [15,19,20]. Indeed, DBD induces mechanical disruption that exposes the proteins of the ECM to reactivate the healing process, allowing exposure of the normal peripheral basal membrane (BM) to the growth of newly formed epithelium, enhancing its adhesion properties [13].…”