Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults: A systematic review and meta-analysis

Fernández‐Rodríguez, Rubén; Álvarez‐Bueno, Celia; Martínez-Ortega, Isabel Antonia; Martínez‐Vizcaíno, Vicente; Mesas, Arthur Eumann; Notario‐Pacheco, Blanca

doi:10.1016/j.jshs.2021.08.004

Cited by 30 publications

(23 citation statements)

References 61 publications

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“…Hence, the available literature suggests that excess neuromodulators in the brain may have adverse effects on cognitive performance during/after highintensity exercise. High-intensity exercise also seems to increase brain-derived neurotrophic factors (BDNFs) (Ferris et al, 2007;Winter et al, 2007;Fernandez-Rodriguez et al, 2021) and insulin-like growth hormone factor-1 (IGF-1) (Sudo et al, 2017). Several studies have implicated that changes in BDNF are associated with cognitive improvement induced by acute exercise (Winter et al, 2007;Lee et al, 2014;Skriver et al, 2014;Hwang et al, 2016).…”

Section: Neuromodulation By Neurotransmitters and Neurotrophic Factorsmentioning

confidence: 99%

The effects of acute high-intensity aerobic exercise on cognitive performance: A structured narrative review

Sudo

Costello

McMorris

et al. 2022

Front. Behav. Neurosci.

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It is well established that acute moderate-intensity exercise improves cognitive performance. However, the effects of acute high-intensity aerobic exercise on cognitive performance have not been well characterized. In this review, we summarize the literature investigating the exercise-cognition interaction, especially focusing on high-intensity aerobic exercise. We discuss methodological and physiological factors that potentially mediate cognitive performance in response to high-intensity exercise. We propose that the effects of high-intensity exercise on cognitive performance are primarily affected by the timing of cognitive task (during vs. after exercise, and the time delay after exercise). In particular, cognitive performance is more likely to be impaired during high-intensity exercise when both cognitive and physiological demands are high and completed simultaneously (i.e., the dual-task paradigm). The effects may also be affected by the type of cognitive task, physical fitness, exercise mode/duration, and age. Second, we suggest that interactions between changes in regional cerebral blood flow (CBF), cerebral oxygenation, cerebral metabolism, neuromodulation by neurotransmitters/neurotrophic factors, and a variety of psychological factors are promising candidates that determine cognitive performance in response to acute high-intensity exercise. The present review has implications for recreational, sporting, and occupational activities where high cognitive and physiological demands are required to be completed concurrently.

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Section: Neuromodulation By Neurotransmitters and Neurotrophic Factorsmentioning

confidence: 99%

The effects of acute high-intensity aerobic exercise on cognitive performance: A structured narrative review

Sudo

Costello

McMorris

et al. 2022

Front. Behav. Neurosci.

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“…When P <.05, there was a significant difference between the intervention group and the control group, proving that the meta-analysis results were statistically significant. Publication bias testing was performed using Stata software (version 16.0; StataCorp) [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

The Effects of Virtual Reality Training on Balance, Gross Motor Function, and Daily Living Ability in Children With Cerebral Palsy: Systematic Review and Meta-analysis

liu¹,

Wang²,

Chen³

et al. 2022

JMIR Serious Games

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Background The increasing number of children with cerebral palsy (CP) has a serious impact on individuals, families, and society. As a new technology, virtual reality (VR) has been used in the rehabilitation of children with CP. Objective This study aimed to systematically evaluate the effect of VR training on balance, gross motor function, and daily living ability in children with CP. Methods PubMed, Embase, The Cochrane Library, Web of Science, and China National Knowledge Infrastructure databases were searched by computer, with the search period being from the establishment of each database to December 25, 2021, to collect randomized controlled trials (RCTs) on the effects of VR training on balance, gross motor function, and daily living ability in children with CP. The Cochrane risk of bias assessment tool was used to conduct quality assessment on the included literature, and RevMan software (version 5.3) was used to analyze data. Results A total of 16 articles were included, involving 513 children with CP. VR training can improve the balance function (Pediatric Balance Scale: mean difference 2.06, 95% CI 1.15-2.97; P<.001; Berg Balance Scale: mean difference 3.66, 95% CI 0.29-7.02; P=.03) and gross motor function (standardized mean difference [SMD] 0.60, 95% CI 0.34-0.87; P<.001) of children with CP. However, there is still certain disagreement on the impact on daily living ability (SMD 0.37, 95% CI –0.04 to 0.78; P=.08); after removing the source literature with heterogeneity, VR training can improve the daily living ability of children with CP (SMD 0.55, 95% CI 0.30-0.81; P<.001). Conclusions VR training can significantly improve the balance function and gross motor function of children with CP, but the effect on the daily living ability of children with CP remains controversial.

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“…Long-term endurance exercise can significantly delay the loss of neuronal volume in the hippocampus area, which underlies some cognitive disorders associated with aging, such as dementia and Alzheimer’s disease [ 267 ]. Several molecules with neurogenesis-stimulating potentials have been shown to be important in exercise-induced neurogenesis in the hippocampus area, including BDNF, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF) [ 285 , 300 , 301 , 302 ]. Importantly, studies have suggested that exercise-induced BDNF is significant in promoting neurogenesis in the elderly population, emphasizing the importance of this mechanism in neuronal healthspan [ 303 ].…”

Section: Central Nervous Systemmentioning

confidence: 99%

Molecular Mechanisms of Exercise and Healthspan

Guan

Yan

2022

Cells

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Healthspan is the period of our life without major debilitating diseases. In the modern world where unhealthy lifestyle choices and chronic diseases taper the healthspan, which lead to an enormous economic burden, finding ways to promote healthspan becomes a pressing goal of the scientific community. Exercise, one of humanity’s most ancient and effective lifestyle interventions, appears to be at the center of the solution since it can both treat and prevent the occurrence of many chronic diseases. Here, we will review the current evidence and opinions about regular exercise promoting healthspan through enhancing the functionality of our organ systems and preventing diseases.

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Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults: A systematic review and meta-analysis

Cited by 30 publications

References 61 publications

The effects of acute high-intensity aerobic exercise on cognitive performance: A structured narrative review

The effects of acute high-intensity aerobic exercise on cognitive performance: A structured narrative review

The Effects of Virtual Reality Training on Balance, Gross Motor Function, and Daily Living Ability in Children With Cerebral Palsy: Systematic Review and Meta-analysis

Molecular Mechanisms of Exercise and Healthspan

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