Immediate Breast Reconstruction in Patients with Locally Advanced Disease

Oncological safety of skin sparing mastectomy followed by immediate reconstruction for locally advanced breast cancer

“…Sultan et al (22 patients) [5] and Newman et al (50 patients) [6] reported that IR after mastectomy for advanced breast cancer patients was oncologically safe, but this study concerned not SSM but modified radical mastectomy.…”

Impact of neoadjuvant chemotherapy on breast reconstruction.

“…In 1 study of 22 patients with locally advanced (stage IIB or III) cancer who received neoadjuvant chemotherapy and underwent immediate reconstruction, there was no delay in adjuvant treatment, but the perioperative morbidity rate was 14%. 19 Another series of 31 patients after neoadjuvant chemotherapy and immediate TRAM flap reconstruction demonstrated an adjuvant treatment delay of 6% and a postoperative complication rate of 55%. 20 In 48 other patients who received neoadjuvant chemotherapy and underwent immediate reconstruction, the mean time between surgery and adjuvant chemotherapy was 26 days.…”

Oncological Considerations for Breast Reconstruction

“…Six percent had a delay in resumption of chemotherapy because of complications. Sultan et al found a 14% complication rate in 21 patients who received neo-adjuvant chemotherapy and underwent IBR [38]. The mean interval between surgery and resumption of chemotherapy was 19 days and there was no delay in any patients.…”