Immediate and later impacts of antimicrobial consumption on carbapenem-resistant Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella spp. in a teaching hospital in Brazil: a 10-year trend study

Federico, Marilia Pinto; Furtado, Guilherme Henrique Campos

doi:10.1007/s10096-018-3352-1

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…[18] The increase of resistance rate of carbapenems may be related to the unreasonable use of carbapenems. [19] Therefore, the control of carbapenem resistant K. pneumoniae in our hospital was the top priority for infection control. Distribution of main pathogens in lower respiratory tract infection (n > 100)…”

Section: Discussionmentioning

confidence: 99%

Characteristics of bacterial etiology in lower respiratory tract infection: a surveillance report from a Chinese large teaching hospital from 2015 to 2019

Tian

Chen

et al. 2020

Preprint

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Background: Lower respiratory tract infection (LRI) is a very common clinical disease. The etiological diagnosis of LRI often depends on the result of sputum culture. Sputum is the most common specimen type of LRI in China, but its cultivation result is easily confused by the bacteria colonized in the oral cavity and pharynx. It is very di cult to evaluate the clinical signi cance of sputum culture results both for clinicians and microbiologists. Fortunately, bronchoscope alveolus lavage uid(BALF)is a good specimen, whose culture results can accurately re ect the situation of LRI. By analyzing the culture results and antimicrobial agents sensitivity data of BALF accumulated in this area, we can provide reference for clinicians to experience in the treatment of lower respiratory tract infection.Methods: The accumulated data of BALF culture and antimicrobial susceptibility test in our hospital from January 2015 to October 2019 were reviewed and analyzed.Results: The positive rate of BALF culture in our hospital was 18.3% (3467/18935) in 2015-2019. The most common pathogens were Klebsiella pneumoniae (18.1%, 627/3467), Pseudomonas aeruginosa (16.9%, 587/3467) and Acinetobacter baumannii (14.0%, 485/3467). For the eight most common pathogens (K. pneumoniae, P. aeruginosa, A. baumannii, Staphylococcus aureus, Haemophilus in uenzae, Stenotrophomonas maltophilia, Escherichia coli and S. pneumoniae), 40-70 years old was the highest age of distribution, but for E. coli and S. pneumoniae, 0-5 years old was also the higher age of distribution. The antibiotic resistance rate of K. pneumoniae to imipenem and meropenem was 30.6%

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Section: Discussionmentioning

confidence: 99%

Characteristics of bacterial etiology in lower respiratory tract infection: a surveillance report from a Chinese large teaching hospital from 2015 to 2019

Tian

Chen

et al. 2020

Preprint

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“…An ecological study conducted at teaching hospitals in Brazil from 2007-2016 showed that increase consumption of β-lactam/β-lactamase inhibitors increased the frequency of carbapenem-resistant Klebsiella spp. with a 1-year time delay [25]. Indeed, increased usage of third-generation cephalosporins was found to be the main independent risk factors of CRKP infections in a retrospective cohort study done in Turkey [26].…”

Section: Discussionmentioning

confidence: 99%

Surveillance of carbapenem-resistant Klebsiella pneumoniae in Chinese hospitals - A five-year retrospective study

Wang

Chen

et al. 2019

J Infect Dev Ctries

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Introduction: Antibiotic consumption is associated with the development of antibiotic resistance. Our aim was to study the relationship between antibiotic consumption and carbapenem-resistant Klebsiella pneumoniae (CRKP) in three public general tertiary hospitals from 2011-2015 in the eastern, western and central regions of China. Methodology: Valid data were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID). Bacterial resistance was reported as the percentage of resistant isolates among all tested isolates. Individual trends were calculated by linear regression, while possible correlations between antibiotic consumption and CRKP were evaluated by distributed lags time series analysis. Results: Over the 5-year period, an overall significant increasing trend (P < 0.1, R2 > 0.3) of carbapenems consumption and the prevalence of CRKP was observed in all three hospitals. This correlated with the use of ceftazidime, cefoperazone/sulbactam, cefminox and meropenem at a hospital in eastern China, with the increased use of meropenem at a hospital in eentral China and with the increased use of doxycycline, ceftriaxone, ceftazidime, meropenem and biapenem at a hospital in western China. Conclusions: We report a high incidence of CRKP in all three hospitals and that an increase in carbapenem usage is associated with this. Further research is needed to elucidate which factors influence the increased consumption of carbapenems.

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confidence: 99%

Bacterial etiology of lower respiratory tract infection in a Chinese large teaching hospital from 2015 to 2019

Tian¹,

Zhang²,

He³

et al. 2019

Preprint

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Background Sputum is the most common specimen type of lower respiratory tract in China, but its cultivation result is easily confused by the bacteria colonized in the oral cavity and pharynx. And it is very difficult to evaluate the clinical significance of sputum culture results both for clinicians and microbiologists. Bronchoscope alveolus lavage fluid(BALF)is a good specimen, which can accurately reflect the situation of lower respiratory tract infections (LRIs).Methods The accumulated data of BALF culture and antimicrobial susceptibility test in our hospital from January 2015 to October 2019 were reviewed and analyzed.Results The positive rate of BALF culture in our hospital was 18.3% (3467/18935) in 2015-2019. The most common pathogens were Klebsiella pneumoniae (18.1%, 627/3467), Pseudomonas aeruginosa (16.9%, 587/3467) and Acinetobacter baumannii (14.0%, 485/3467). For the eight most common pathogens, 40-70 years old was the highest age of distribution, but for Escherichia coli and Streptococcus pneumoniae, 0-5 years old was also the higher age of distribution. The antibiotic resistance rate of K. pneumoniae to imipenem and meropenem was 30.6% and 30.8%, respectively. The sensitivity of P. aeruginosa to antibiotics other than minocycline and ticarcillin clavulanic acid was all more than 60%. However, the resistance rate of A. baumannii to antibiotics other than tegacyclin and minocycline was all more than 80%.Conclusions 40-70 years old was the high incidence age of lower respiratory tract bacterial infection. K. pneumoniae resistant to carbapenems ( CR-K. pneumoniae ) and A. baumannii were a great challenge to clinical treatment and bacterial resistance control.

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Immediate and later impacts of antimicrobial consumption on carbapenem-resistant Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella spp. in a teaching hospital in Brazil: a 10-year trend study

Cited by 11 publications

References 20 publications

Characteristics of bacterial etiology in lower respiratory tract infection: a surveillance report from a Chinese large teaching hospital from 2015 to 2019

Characteristics of bacterial etiology in lower respiratory tract infection: a surveillance report from a Chinese large teaching hospital from 2015 to 2019

Surveillance of carbapenem-resistant Klebsiella pneumoniae in Chinese hospitals - A five-year retrospective study

Bacterial etiology of lower respiratory tract infection in a Chinese large teaching hospital from 2015 to 2019

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