Surveillance of carbapenem-resistant Klebsiella pneumoniae in Chinese hospitals - A five-year retrospective study

Qu, Xiaoyuan; Wang, Haipeng; Chen, Chaoran; Tao, Zhimin; Yin, Chang Yi; Yin, Aihua; Ma, Chunyan; Idris, Adi

doi:10.3855/jidc.11798

Cited by 11 publications

(13 citation statements)

References 22 publications

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“…The rapid increase in carbapenem-resistant Enterobacteriaceae (CRE) has been reported both locally and globally [12][13][14]30,31]. This increase in CRE is linked to the increased use and consumption of β-lactamase inhibitors [32,33].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiogram Pattern of Klebsiella pneumoniae in a Tertiary Care Hospital in Makkah, Saudi Arabia: An 11-Year Experience

et al. 2023

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Infectious disease is one of the greatest causes of morbidity and mortality worldwide, and with the emergence of antimicrobial resistance, the situation is worsening. In order to prevent this crisis, antimicrobial resistance needs to be monitored carefully to control the spread of multidrug-resistant bacteria. Therefore, in this study, we aimed to determine the prevalence of infection caused by Klebsiella pneumoniae and investigate the antimicrobial profile pattern of K. pneumoniae in the last eleven years. This retrospective study was conducted in a tertiary hospital in Makkah, Saudi Arabia. Data were collected from January 2011 to December 2021. From 2011 to 2021, a total of 61027 bacterial isolates were collected from clinical samples, among which 14.7% (n = 9014) were K. pneumoniae. The antibiotic susceptibility pattern of K. pneumoniae revealed a significant increase in the resistance rate in most tested antibiotics during the study period. A marked jump in the resistance rate was seen in amoxicillin/clavulanate and piperacillin/tazobactam, from 33.6% and 13.6% in 2011 to 71.4% and 84.9% in 2021, respectively. Ceftazidime, cefotaxime, and cefepime resistance rates increased from 29.9%, 26.2%, and 53.9%, respectively, in 2011 to become 84.9%, 85.1%, and 85.8% in 2021. Moreover, a significant increase in the resistance rate was seen in both imipenem and amikacin, with an average resistance rate rise from 6.6% for imipenem and 11.9% for amikacin in 2011 to 59.9% and 62.2% in 2021, respectively. The present study showed that the prevalence and drug resistance of K. pneumoniae increased over the study period. Thus, preventing hospital-acquired infection and the reasonable use of antibiotics must be implemented to control and reduce antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiogram Pattern of Klebsiella pneumoniae in a Tertiary Care Hospital in Makkah, Saudi Arabia: An 11-Year Experience

et al. 2023

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“…22 In addition, increasing consumption of β-lactam/β-lactamase inhibitors may also increase the frequency of carbapenem-resistant Klebsiella spp. [23][24][25] K. pneumoniae can cause serious, life-threatening infections in humans in endemic and epidemic settings. 26 Resistance to carbapenems in Enterobacteriales is primarily linked to different mechanisms, in particular the production of carbapenemases.…”

Section: Discussionmentioning

confidence: 99%

Resistance Trends of Klebsiella pneumoniae Causing Urinary Tract Infections in Chongqing, 2011–2019

Ding¹,

Wang²,

Pu³

et al. 2021

IDR

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Purpose To analyze the characteristics and trends of drug resistance for Klebsiella pneumoniae ( K. pneumoniae ), isolated from urinary tract infections (UTIs), to common antibiotics used in clinics. Methods This retrospective study was conducted in a teaching hospital in Chongqing from 2011 to 2019. Laboratory data of isolated bacteria were collected and analyzed. Results Among the 17,966 non-repetitive strains isolated from the urine sample, a total of 1543 K. pneumoniae isolates were identified, with an isolation frequency secondary only to Escherichia coli ( E. coli ) and there was a peak in the K. pneumoniae isolates in the year 2013. During the period, the rate of extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae fell from 48.4% in 2011 to 32.9% in 2019, and a marked jump of resistance was seen in carbapenems from 2.2% to 18.0%. The peak of carbapenem resistance rate (22.6%) to K. pneumoniae was observed in 2017 along with a low ESBL-producing rate (30.9%). Piperacillin/tazobactam and cefepime resistance levels went up from 4.4% to 25.7% and from 18.2% to 30.5%, respectively. Moreover, the K. pneumoniae isolates resistance rate to carbapenems and amikacin gradually grew up, showing their peaks in 2017, and then dropped year by year. However, ceftazidime and aztreonam resistance levels were relatively stable, fluctuating between 21.8% and 35.6%, 32.2% and 39.4%, respectively. Conclusion There is a significant upward tendency in carbapenem resistance rate and a downward tendency in ESBL-production rate in K. pneumoniae isolates from UTIs, and continuous surveillance is necessary in the future.

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“…Las tasas de aislamientos clínicos de Enterobacterales productores de carbapenemasas son del 1,7% en España [15] y de colonización del 2% [22], la mismas pueden variar del 13,4% al 73,1% dependiendo del país [4,17,[23][24][25][26], los microorganismos predominantes son K. pneumoniae y E. coli [24]. En este trabajo la tasa de colonización se encuentra dentro de los valores estimados para España, y se demuestra que la detección de estos microorganismos en FR juega un papel preponderante, incluso pudiendo predecir la infección.…”

Section: Tabla 2 Microorganismos Aislados En Estudios Simultáneos En Frotis Rectal (Fr) Y Faríngeo (Ff)unclassified

“…Otra limitación, es que no fue posible determinar los antimicrobianos utilizados para el tratamiento de la infección, de manera que podamos justificar la presencia de cultivos negativos o discordantes asociados al uso de antibióticos. ta 5 veces el riesgo de muerte y el riesgo de bacteriemias en pacientes sometidos a trasplantes alogénicos de médula ósea [24,25,27] La muestra ideal para la detección de colonizados parece ser la rectal, y así lo determinan la mayoría de los estudios de colonización [4,17,26], incluido el nuestro.…”

Section: P Aeruginosaunclassified

Infections in patients colonized with carbapenem-resistant Gram-negative bacteria in a medium Spanish city

Soria‐Segarra¹,

Delgado-Valverde²,

Serrano-García³

et al. 2021

Rev Esp Quimioter

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Objective. Because there are few studies on the clinical implications of colonization by carbapenem-resistant gram-negative bacteria (CRB) this was analyzed in rectal smears (RS) and pharyngeals (PS) and its ability to predict infection/colonization. Methodology. A cross-sectional, retrospective study from adult inpatients between January 2016 and December 2019 was conducted. The isolates were characterized by MicroScan and spectrometry of masses applying EUCAST 2018 cutoff points. The detection of carbapenemases was performed by PCR and Sanger sequencing; sequencies was assigned by MLST. The genetic relationship between the clinical isolates was made by pulsed field electrophoresis using the enzymes Xbal, Spel or Apal. Results. A total of 308 (86.03%) RS and 50 (13.97%) positive PS were detected, the RS had a 85% sensibility, 100% specificity, 100% positive predictive value and 97% negative predictive value. In RS, the following were isolated: 44% (n=135) Acinetobacter baumannii, 26% (n =80) Enterobacterales (20 KPC, 29 OXA-48, 22 VIM, 2 IMP, 7 NDM), 17% (n=53) Pseudomonas aeruginosa and 13% (n=40) Stenotrophomonas maltophilia. In the PS were isolated 44% (n=22) S. maltophilia, 40% (n = 20) A. baumannii, 8% (n=4) P. aeruginosa and 8% (n=4) Enterobacterales (3 VIM, 1 OXA). From the patients with simultaneous RS and PS, 41 (40.6%) had positivity in both smears, 45 (44.6%) only in RS and 15 (14.9%) only in PS. Colonization preceded infection in 81.3% (n=13) of the isolates; association between infection and colonization was found (p<0.001; χ2); and the episodes where the information was found all the isolates from the clinical samples and from the smears were similar. Conclusions. The probability of predicting infection through the CRB colonized in different clinical samples is feasible. The RS has a major sensibility to detect colonization.

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Surveillance of carbapenem-resistant Klebsiella pneumoniae in Chinese hospitals - A five-year retrospective study

Cited by 11 publications

References 22 publications

Prevalence and Antibiogram Pattern of Klebsiella pneumoniae in a Tertiary Care Hospital in Makkah, Saudi Arabia: An 11-Year Experience

Prevalence and Antibiogram Pattern of Klebsiella pneumoniae in a Tertiary Care Hospital in Makkah, Saudi Arabia: An 11-Year Experience

Resistance Trends of Klebsiella pneumoniae Causing Urinary Tract Infections in Chongqing, 2011–2019

Infections in patients colonized with carbapenem-resistant Gram-negative bacteria in a medium Spanish city

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