Immediate‐ and delayed‐type allergic reactions to amide local anesthetics: clinical features and skin testing

Fuzier, Régis; Lapeyre‐Mestre, Maryse; Mertès, Paul-Michel; Nicolas, Jean‐François; Benoit, Yves; Didier, A.; Albert, Natalie; Montastruc, Jean‐Louis

doi:10.1002/pds.1758

Cited by 74 publications

(46 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The causative drug classes with significant reported odds ratio (ROR) were antibiotics (2.92, 95% CI 2. 71 [45]. Local anaesthetic allergic reactions occurred mostly in young females (female : male sex ratio 14:2).…”

Section: Studies From Pharmacovigilance Databasesmentioning

confidence: 99%

Epidemiology and risk factors for drug allergy

Thong

Tan

2011

Brit J Clinical Pharma

298

218

View full text Add to dashboard Cite

The aim of this review was to describe the current evidence-based knowledge of the epidemiology, prevalence, incidence, risk factors and genetic associations of drug allergy. Articles published between 1966 and 2010 were identified in MEDLINE using the key words adult, adverse drug reaction reporting systems, age factors, anaphylactoid, anaphylaxis, anaesthetics, antibiotics, child, drug allergy, drug eruptions, ethnic groups, hypersensitivity, neuromuscular depolarizing agents, neuromuscular nondepolarizing agents, sex factors, StevensJohnson syndrome and toxic epidermal necrolysis. Additional studies were identified from article reference lists. Relevant, peer-reviewed original research articles, case series and reviews were considered for review. Current epidemiological studies on adverse drug reactions (ADRs) have used different definitions for ADR-related terminology, often do not differentiate immunologically and non-immunologically mediated drug hypersensitivity, study different study populations (different ethnicities, inpatients or outpatients, adults or children), utilize different methodologies (spontaneous vs. non-spontaneous reporting, cohort vs. case-control studies), different methods of assessing drug imputability and different methods of data analyses. Potentially life-threatening severe cutaneous adverse reactions (SCAR) are associated with a high risk of morbidity and mortality. HLA associations for SCAR associated with allopurinol, carbamazepine and abacavir have been reported with the potential for clinical use in screening prior to prescription. Identification of risk factors for drug allergy and appropriate genetic screening of at-risk ethnic groups may improve the outcomes of drug-specific SCAR. Research and collaboration are necessary for the generation of clinically-relevant, translational pharmacoepidemiological and pharmacogenomic knowledge, and success of health outcomes research and policies on drug allergies.

show abstract

Section: Studies From Pharmacovigilance Databasesmentioning

confidence: 99%

Epidemiology and risk factors for drug allergy

Thong

Tan

2011

Brit J Clinical Pharma

298

218

View full text Add to dashboard Cite

show abstract

“…Local anesthetics are among the most commonly used drugs in clinical medicine; however, a variety of adverse drug reactions have been reported 1-5. Acute disorientation or seizures may occur after overdosing or inadvertent intravenous injection.…”

Section: Discussionmentioning

confidence: 99%

“…Allergic reactions to local anesthetics are very rare and represent <1% of all adverse local anesthetics reactions 1-4. Contact dermatitis is the most commonly reported allergic reaction to several amide-type local anesthetics 5-7.…”

Section: Introductionmentioning

confidence: 99%

Bronchospasm and Anaphylactic Shock Following Lidocaine Aerosol Inhalation in a Patient with Butane Inhalation Lung Injury

Lee

Park

Yeo

et al. 2011

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

Allergic reactions to local anesthetics are very rare and represent <1% of all adverse local anesthetics reactions. A 54-year-old man was admitted to the hospital in the winter because of shortness of breath. The patient reportedly had an inhalation lung injury due to butane gas fuel. On the fifth day, he developed an asthmatic attack and anaphylactic shock immediately after lidocaine aerosol administration to prepare for bronchoscopy to confirm an acute inhalational lung injury diagnosis. Cardiopulmonary resuscitation was performed immediately after respiratory arrest, and the patient was admitted to the intensive care unit intubated and on a ventilator. He was extubated safely on the third post-cardiopulmonary resuscitation day. These observations suggest that aerosol lidocaine anesthesia may cause airway narrowing and anaphylactic shock. Practitioners should be aware of this potential complication. We report on this case with a brief review of the literature.

show abstract

“…Considering sex as a risk factor, current studies continue to argue in favor of the female sex as a risk factor for developing ADRs [12][13][14]. It was also found that atopy may be a risk factor for developing sensitization to betalactam antibiotics in tertiary hospital nurses [15].…”

Section: Recent Findingsmentioning

confidence: 92%

“…A historical French study [14] found 16 reports of amidetype local anesthetic allergic reactions documented with a clear and detailed medical history and a positive skin test. An immediate-type allergic reaction was encountered in 11/16 cases.…”

Section: Cross-reactions Between Amide Local Anestheticsmentioning

confidence: 99%