Immature platelet fraction related parameters in the differential diagnosis of thrombocytopenia

Li, Junxun; Li, Ying; Ouyang, Jian; Zhang, Fan; Liang, Chujia; Ye, Zhuangjian; Chen, Shaoqian; Cheng, Jing

doi:10.1080/09537104.2019.1678118

Cited by 11 publications

(11 citation statements)

References 19 publications

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“…Thrombocytopenia can be observed in severe iron deficiency, and clinicians should be aware of this rare event (less than 50 reported cases 55,63–66 ). It can be falsely diagnosed as an immune thrombocytopenia that can be associated with iron deficiency secondary to bleeding 67 . Two factors may favor the diagnosis of iron deficiency related thrombocytopenia: (i) the severity of iron deficiency with marked decreases in hemoglobin, MCV (erythrocyte mean corpuscular volume), and ferritin values; and (ii) a low percentage of reticulated platelets (or low immature platelet fraction) (IPF), which orientates toward a central thrombocytopenia (a state of impaired platelet production, as opposed to the increased destruction by autoimmune attack as occurring in immune thrombocytopenia) 66,68 .…”

Section: Iron and Platelets: Clinical And Mechanistic Aspects Iron Deficiency And Plateletsmentioning

confidence: 99%

Iron and platelets: A subtle, under‐recognized relationship

et al. 2021

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Section: Iron and Platelets: Clinical And Mechanistic Aspects Iron Deficiency And Plateletsmentioning

confidence: 99%

Iron and platelets: A subtle, under‐recognized relationship

et al. 2021

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“…Despite the poor standardization and a lack of correlation between the young platelet fraction measurements among the different instruments (absence of reference method and the existence of different reference ranges for different instruments), these parameters are good indicators of thrombopoietic activity [20][21][22]. IPF absolute count has been proven as an indicator of platelet recovery after chemotherapy in pediatrics [23] and, thus, has been proposed as a tool to categorize neonatal thrombocytopenia [24] or to predict peripheral immune thrombocytopenia [25,26]. IPF increases in diseases when there is increased platelet destruction or consumption and decreases in bone marrow failure.…”

Section: Fluorescence Platelet Countingmentioning

confidence: 99%

Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC)

Baccini

Geneviève

Jacqmin

et al. 2020

JCM

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Despite the ongoing development of automated hematology analyzers to optimize complete blood count results, platelet count still suffers from pre-analytical or analytical pitfalls, including EDTA-induced pseudothrombocytopenia. Although most of these interferences are widely known, laboratory practices remain highly heterogeneous. In order to harmonize and standardize cellular hematology practices, the French-speaking Cellular Hematology Group (GFHC) wants to focus on interferences that could affect the platelet count and to detail the verification steps with minimal recommendations, taking into account the different technologies employed nowadays. The conclusions of the GFHC presented here met with a "strong professional agreement" and are explained with their rationale to define the course of actions, in case thrombocytopenia or thrombocytosis is detected. They are proposed as minimum recommendations to be used by each specialist in laboratory medicine who remains free to use more restrictive guidelines based on the patient's condition.

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“…The thrombopoiesis can be identified by immature platelet fraction (IPF%), because of rise in percentage with adequate megakaryocytic activity and high turnover, in contrast, to decrease in percentage and low megakaryocytic activity with low turnover of the platelet. 3,4 Sysmex XN analyzer is used for the measurement of immature platelet fraction, which evaluate young or immature platelets in peripheral blood in proportion to total platelet count (IPF%). Their lifetime is less than 24 hours.…”

Section: Original Articlementioning

confidence: 99%

“…5 Sysmex automated blood cell analyzers are used to develop immature platelet fraction related parameters like immature platelet fraction count, immature platelet fraction percentage and highly fluorescent mature platelet fraction percentage (H-IPF%). 6 Thrombocytopenia due to increased platelet destruction can be identified based on an increase in IPF#, and IPF% which can be measured by Sysmex XE series and is considered to be effective in the differential diagnosis of thrombocytopenia. 7 Thrombocytopenia is a frequently associated complication of advanced liver disease and its incidence further increases in liver cirrhosis patients, ranging from 77% -85%.…”

Section: Original Articlementioning

confidence: 99%

Immature Platelet Fraction in Patients with Chronic Liver Disease, A Marker for Evaluating Cirrhotic Changes.

Iqbal

Usman

Anjum

et al. 2021

Ann Pak Inst Med Sci

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Objective: To evaluate the role of Immature platelet fraction in patients with chronic liver disease, a marker for evaluating cirrhotic changes. Methodology: This case control study was conducted at department of Pathology, Aziz Fatima Medical and Dental College, Faisalabad, over a period of Seven months from June 2020 to January 2021. A total of 126 participants were included in the study consisting of 63 patients with chronic liver disease in group A and 63 participants without any known disease in group B as control. The IPF master program in combination with XE-2100 multiparameter automatic hematology analyzer was used to measure the immature platelet fraction. Ethylene diamine tetraacetic acid was used to collect the blood sample for IPF measurement and was maintained till analysis on room temperature. Ten repeated analyses, immediately and after 24 hours were done for reproducibility of IPF%. Results: The mean age of liver disease patients was 52.35 ± 13.64 years and in control group the mean age was 51.62 ± 11.27 years. There was no significant (p-value > 0.05) difference between both groups based on age and gender. The hemoglobin level and red cell count was found to be significantly (p-value < 0.05) reduced in cases group. While white blood cells count was comparable in both groups. The mean platelet count was significantly (p-value < 0.05) less in cases group (163.5 ± 90.4 vs 233.4 ± 54.5 (x10*3/µl). The mean value of immature platelet fraction (IPF%) was significantly (p-value < 0.05) raised in cases group (5.62 ± 2.92 vs 3.06 ± 1.87). The multivariate discriminant analysis (MDA) score showed a significant (p-value < 0.05) association with chronic hepatis as compared to other liver related diseases. Conclusions: In chronic liver disease patients, there is an inverse relationship between platelet count and IPF% with decreased platelet count and increased IPF%. The proposed MDA function can be used to identify the cirrhotic changes in liver disease patients.

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Immature platelet fraction related parameters in the differential diagnosis of thrombocytopenia

Cited by 11 publications

References 19 publications

Iron and platelets: A subtle, under‐recognized relationship

Iron and platelets: A subtle, under‐recognized relationship

Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC)

Immature Platelet Fraction in Patients with Chronic Liver Disease, A Marker for Evaluating Cirrhotic Changes.

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